caa a22 4500 445310014 CHVBK 20180317142626.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s00404-010-1697-5 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1697-5 Does primary breast cancer in older women (≥80years) have unfavorable histological characteristics? [Elektronische Daten] [Paraskevi Chatzidaki, Chrysovalantis Mellos, Volker Briese, Ioannis Mylonas] Introduction: Although the majority of breast cancer patients are older than 65years, limited data exist regarding the pathological features in very elderly patients. The aim of this study was to evaluate the histological characteristics of breast cancer in women aged over 80years. Methods: The histological data were reviewed for 137 women aged 80years and older who were diagnosed with primary breast carcinoma at a university clinic during the period 1990-2005. Results: Although it is believed that older women have more advanced tumor, the majority of the tumors were assessed as stage I (35%) and II (32.9%). Mucinous, papillary, medullary, tubular, and cribriform histological subtypes have been demonstrated often in this age group (16.8%). In 49.7 and 70.6% of cases, respectively, there were no regional lymph node metastases and no distant metastases. The frequency of ER-positive (72%) and PR-positive (56%) tumors in these patients is high. Conclusions: An accurate prognostic evaluation at the time of initial diagnosis is of high importance for older patients, since this could avoid unnecessary and risky therapies. As an increasing number of women≥80years old may be diagnosed with breast cancer in the coming years, treatment in this specific age group should be individualized to the patient and tumor factors. Springer-Verlag, 2010 Breast cancer nationallicence Histology nationallicence Prognostic parameters nationallicence Older women (≥80years) nationallicence Chatzidaki Paraskevi Department of Obstetrics and Gynecology, University of Rostock, Rostock, Germany aut Mellos Chrysovalantis General Hospital of Corinthos, Corinthos, Greece aut Briese Volker Department of Obstetrics and Gynecology, University of Rostock, Rostock, Germany aut Mylonas Ioannis First Department of Obstetrics and Gynecology, Ludwig-Maximilians-University Munich, Maistrasse 11, 80337, Munich, Germany aut Archives of Gynecology and Obstetrics Springer-Verlag 284/3(2011-09-01), 705-712 0932-0067 284:3<705 2011 284 404 https://doi.org/10.1007/s00404-010-1697-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1697-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chatzidaki Paraskevi Department of Obstetrics and Gynecology, University of Rostock, Rostock, Germany aut NATIONALLICENCE 700 1- Mellos Chrysovalantis General Hospital of Corinthos, Corinthos, Greece aut NATIONALLICENCE 700 1- Briese Volker Department of Obstetrics and Gynecology, University of Rostock, Rostock, Germany aut NATIONALLICENCE 700 1- Mylonas Ioannis First Department of Obstetrics and Gynecology, Ludwig-Maximilians-University Munich, Maistrasse 11, 80337, Munich, Germany aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 284/3(2011-09-01), 705-712 0932-0067 284:3<705 2011 284 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer