caa a22 4500 445310065 CHVBK 20180317142626.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s00404-010-1732-6 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1732-6 Beneficial effects of dienogest on uterine myoma volume: a retrospective controlled study comparing with gonadotropin-releasing hormone agonist [Elektronische Daten] [Satoshi Ichigo, Hiroshi Takagi, Kazutoshi Matsunami, Noriko Suzuki, Atsushi Imai] Purpose: Uterine leiomyomas are the most common benign tumors of reproductive age women, but there is no effective medical therapy to data. Aim of this study was to examine and compare the efficacy of gonadotropin-releasing hormone agonist (GnRHa) versus dienogest in premenopausal women with uterine myoma. Methods: We retrospectively analyzed the medical records of 55 premenopausal patients with endometriosis, who received dienogest (2mg daily) for 6 months regarding coexistence of uterine myoma between January 2008 and June 2010. To compare these data in a case-control study, we analyzed a matched control group of 12 patients treated with leuprolide acetate (1.88mg monthly) for 6 months having uterine myoma. Results: Of the 55 patients treated with dienogest, six were associated with coexistent myoma node. Total myoma volume significantly decreased to 59.7±7.0% of initial in dienogest group and 51.9±5.5% in GnRHa group. Reduction rate in myoma volume was similar in both groups. Conclusion: Uterine myoma volume was successfully reduced by use of dienogest. Consideration of GnRHa disadvantages may lead to short- or long-term management of women with myoma who are to be managed transiently, and who wish to avoid surgical intervention, especially perimenopausal women. Springer-Verlag, 2010 Uterine leiomyoma nationallicence Medical therapy nationallicence Dienogest nationallicence Leuprolide acetate nationallicence Ichigo Satoshi Department of Obstetrics and Gynecology, Matsunami General Hospital, 501-6062, Gifu, Japan aut Takagi Hiroshi Department of Obstetrics and Gynecology, Matsunami General Hospital, 501-6062, Gifu, Japan aut Matsunami Kazutoshi Department of Obstetrics and Gynecology, Matsunami General Hospital, 501-6062, Gifu, Japan aut Suzuki Noriko Department of Obstetrics and Gynecology, Gifu University School of Medicine, 501-1194, Gifu, Japan aut Imai Atsushi Institute of Endocrine-Related Cancer, Matsunami General Hospital, 501-6062, Gifu, Kasamatsu, Japan aut Archives of Gynecology and Obstetrics Springer-Verlag 284/3(2011-09-01), 667-670 0932-0067 284:3<667 2011 284 404 https://doi.org/10.1007/s00404-010-1732-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1732-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ichigo Satoshi Department of Obstetrics and Gynecology, Matsunami General Hospital, 501-6062, Gifu, Japan aut NATIONALLICENCE 700 1- Takagi Hiroshi Department of Obstetrics and Gynecology, Matsunami General Hospital, 501-6062, Gifu, Japan aut NATIONALLICENCE 700 1- Matsunami Kazutoshi Department of Obstetrics and Gynecology, Matsunami General Hospital, 501-6062, Gifu, Japan aut NATIONALLICENCE 700 1- Suzuki Noriko Department of Obstetrics and Gynecology, Gifu University School of Medicine, 501-1194, Gifu, Japan aut NATIONALLICENCE 700 1- Imai Atsushi Institute of Endocrine-Related Cancer, Matsunami General Hospital, 501-6062, Gifu, Kasamatsu, Japan aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 284/3(2011-09-01), 667-670 0932-0067 284:3<667 2011 284 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer