caa a22 4500 44531009X CHVBK 20180317142626.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s00404-010-1712-x doi (NATIONALLICENCE)springer-10.1007/s00404-010-1712-x Pilot study into the efficacy of foetal fibronectin testing in minimising hospital admissions in women presenting with symptoms of preterm labour: a randomised controlled trial of obstetric and neonatal outcomes [Elektronische Daten] [Debarati Dutta, Jane Norman] Aims: The purpose of this pilot study was to determine the role of foetal fibronectin (fFN) testing in women presenting to hospital with symptoms of preterm labour in reducing the hospital admissions, without significantly increasing the risk of preterm birth and neonatal respiratory distress syndrome. Methods: Women with symptoms of preterm labour were assigned randomly to receive fFN (n=44) or to preterm labour management without fFN (n=44). In the testing arm, the result of the test was revealed to the clinician. Clinical outcomes were compared in the two groups. The time period covered by the randomised controlled trial (RCT) was from December 2007 to March 2009. The RCT was conducted in two large maternity units in the west of Scotland, one in Glasgow the other in Ayrshire. Results: All the women with fibronectin positive got admitted while only 32.4% of the fibronectin negatives were admitted (P=0.002). There was a significant difference in the mean length of stay between the fibronectin positives which was 47.17h, and the negatives which was 12.9h (P=0.018). Overall the control and testing arms did not differ in respect to admissions and length of stay. 5 out of 7 positives and 11 out of 37 negatives had corticosteroids (P=0.089). 2 out of 7 positives and 1 out of 37 negatives had tocolytics (P=0.073). Conclusions: Those who had the fFN test done were less likely to be admitted in the hospital and had a shorter length of stay, without any increase in the adverse maternal or foetal effects, avoiding unnecessary admissions. Springer-Verlag, 2010 Foetal fibronectin nationallicence Preterm labour nationallicence Hospital admissions nationallicence Length of stay nationallicence Neonatal outcomes nationallicence Dutta Debarati Crosshouse Hospital, Kilmarnock, 50, Springhill Avenue, Crosshouse, KA2 0JP, Kilmarnock, UK aut Norman Jane Centre for Reproductive Biology, The Queens Medical Research Institute, University of Edinburgh, 47, Little France Crescent, EH16 4TJ, Edinburgh, UK aut Archives of Gynecology and Obstetrics Springer-Verlag 284/3(2011-09-01), 559-565 0932-0067 284:3<559 2011 284 404 https://doi.org/10.1007/s00404-010-1712-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1712-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dutta Debarati Crosshouse Hospital, Kilmarnock, 50, Springhill Avenue, Crosshouse, KA2 0JP, Kilmarnock, UK aut NATIONALLICENCE 700 1- Norman Jane Centre for Reproductive Biology, The Queens Medical Research Institute, University of Edinburgh, 47, Little France Crescent, EH16 4TJ, Edinburgh, UK aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 284/3(2011-09-01), 559-565 0932-0067 284:3<559 2011 284 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer