caa a22 4500 445310146 CHVBK 20180317142626.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s00404-011-1924-8 doi (NATIONALLICENCE)springer-10.1007/s00404-011-1924-8 Prognostic value of total testosterone for pregnancy during treatment in patients with clomiphene-citrate-resistant polycystic ovary syndrome: a pilot study [Elektronische Daten] [Chunyang Li, Jing Cheng, Jianguang Wang, Yamei Xue, Zhaoxia Huang, Shengkun Zhang, Jieqiang Lv] Purpose: Reduction of serum total testosterone (TT) is associated with pregnancy rate in polycystic ovary syndrome (PCOS) women receiving metformin, but most of the studies focus on the changes of basal levels of TT. The aim of this study was to evaluate whether the TT level around the ovulation period is related to the outcome of pregnancy in women with PCOS. Methods: In total, 30 non-obese PCOS women with clomiphene citrate (CC) resistance from the Medical College's Reproductive Health Center were enrolled and randomly assigned to be treated with placebo (Group 1) or metformin (850mg) (Group 2) twice daily for 3months as the pre-treatment. Then, metformin alone was administered with CC, human menopausal gonadotropin (HMG) and human chorionic gonadotropin (HCG) to induce ovulation for 3months in Group 1. In Group 2, CC/HMG/HCG was used to induce ovulation for 3months without metformin. Follicle-stimulating hormone, luteinizing hormone, estradiol and TT levels before and after ovulation in pregnant cycles and non-pregnant cycles were evaluated over the course of treatment. Results: A total of 26 subjects completed 65 cycles. The TT levels after ovulation in the pregnant cycles were significantly lower than in the non-pregnant cycles in both groups (P=0.001 and P<0.001, respectively). Conclusions: The level of TT after ovulation may be of prognostic value for pregnancy in non-obese women with PCOS and CC resistance during treatment. Springer-Verlag, 2011 Testosterone nationallicence Pregnancy nationallicence Polycystic ovary syndrome nationallicence Ovulation induction nationallicence Li Chunyang Staff Room of Biochemistry, The Basic Medical College of Wenzhou Medical College, 325000, Wenzhou, Zhejiang, China aut Cheng Jing Reproductive Health Center, The Second Affiliated Hospital of Wenzhou Medical College, 325000, Wenzhou, Zhejiang, China aut Wang Jianguang Staff Room of Biochemistry, The Basic Medical College of Wenzhou Medical College, 325000, Wenzhou, Zhejiang, China aut Xue Yamei Reproductive Health Center, The Second Affiliated Hospital of Wenzhou Medical College, 325000, Wenzhou, Zhejiang, China aut Huang Zhaoxia Reproductive Health Center, The Second Affiliated Hospital of Wenzhou Medical College, 325000, Wenzhou, Zhejiang, China aut Zhang Shengkun Staff Room of Biochemistry, The Basic Medical College of Wenzhou Medical College, 325000, Wenzhou, Zhejiang, China aut Lv Jieqiang Reproductive Health Center, The Second Affiliated Hospital of Wenzhou Medical College, 325000, Wenzhou, Zhejiang, China aut Archives of Gynecology and Obstetrics Springer-Verlag 284/3(2011-09-01), 757-764 0932-0067 284:3<757 2011 284 404 https://doi.org/10.1007/s00404-011-1924-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-011-1924-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Li Chunyang Staff Room of Biochemistry, The Basic Medical College of Wenzhou Medical College, 325000, Wenzhou, Zhejiang, China aut NATIONALLICENCE 700 1- Cheng Jing Reproductive Health Center, The Second Affiliated Hospital of Wenzhou Medical College, 325000, Wenzhou, Zhejiang, China aut NATIONALLICENCE 700 1- Wang Jianguang Staff Room of Biochemistry, The Basic Medical College of Wenzhou Medical College, 325000, Wenzhou, Zhejiang, China aut NATIONALLICENCE 700 1- Xue Yamei Reproductive Health Center, The Second Affiliated Hospital of Wenzhou Medical College, 325000, Wenzhou, Zhejiang, China aut NATIONALLICENCE 700 1- Huang Zhaoxia Reproductive Health Center, The Second Affiliated Hospital of Wenzhou Medical College, 325000, Wenzhou, Zhejiang, China aut NATIONALLICENCE 700 1- Zhang Shengkun Staff Room of Biochemistry, The Basic Medical College of Wenzhou Medical College, 325000, Wenzhou, Zhejiang, China aut NATIONALLICENCE 700 1- Lv Jieqiang Reproductive Health Center, The Second Affiliated Hospital of Wenzhou Medical College, 325000, Wenzhou, Zhejiang, China aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 284/3(2011-09-01), 757-764 0932-0067 284:3<757 2011 284 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer