caa a22 4500 445310170 CHVBK 20180317142627.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s00404-011-1947-1 doi (NATIONALLICENCE)springer-10.1007/s00404-011-1947-1 Co-involvement of psychological and neurological abnormalities in infertility with polycystic ovarian syndrome [Elektronische Daten] [Xiaobo Shi, Lingyan Zhang, Shuxin Fu, Na Li] Objective: To investigate psychological distress, serum levels of monoamine neurotransmitters and their metabolites, as well as their correlation with polycystic ovarian syndrome (PCOS). Methods: Thirty infertility patients with PCOS were assigned as the experimental group and 30 infertility patients without PCOS were assigned as the control group. Psychological distress was self-evaluated in all patients with Symptom Checklist 90 (SCL-90). Serum concentrations of norepinephrine (NE) and its metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG), 5-hydroxytryptamine (5-HT) and its metabolite 5-hydroxyindoleacetic acid (5-HIAA), dopamine (DA) and its metabolites homovanillic acid (HVA) and dihydroxy-phenyl acetic acid (DOPAC) were measured by high-performance liquid chromatography. Results: The anxious and depressive subscales of SCL-90 were significantly higher in infertility patients with PCOS than those without PCOS (p<0.05). The serum concentrations of 5-HT, 5-HIAA and HVA were significantly lower in infertility patients with PCOS than those without PCOS (p<0.05). Importantly, the phobia subscale scores of SCL-90 positively correlated with serum MHPG level (p<0.05), while the hostility subscale's scores negatively correlated with serum DOPAC level (p<0.05). Conclusion: Psychological and neurological factors play a crucial role in PCOS. Springer-Verlag, 2011 Polycystic ovarian syndrome nationallicence Depression nationallicence Anxiety nationallicence Neurotransmitter nationallicence Infertility nationallicence Shi Xiaobo Department of Gynecology and Obstetrics, Second Xiangya Hospital, Central South University, 410011, Changsha, Hunan, China aut Zhang Lingyan Department of Gynecology and Obstetrics, Second Xiangya Hospital, Central South University, 410011, Changsha, Hunan, China aut Fu Shuxin Department of Gynecology and Obstetrics, Second Xiangya Hospital, Central South University, 410011, Changsha, Hunan, China aut Li Na Department of Gynecology and Obstetrics, Second Xiangya Hospital, Central South University, 410011, Changsha, Hunan, China aut Archives of Gynecology and Obstetrics Springer-Verlag 284/3(2011-09-01), 773-778 0932-0067 284:3<773 2011 284 404 https://doi.org/10.1007/s00404-011-1947-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-011-1947-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Shi Xiaobo Department of Gynecology and Obstetrics, Second Xiangya Hospital, Central South University, 410011, Changsha, Hunan, China aut NATIONALLICENCE 700 1- Zhang Lingyan Department of Gynecology and Obstetrics, Second Xiangya Hospital, Central South University, 410011, Changsha, Hunan, China aut NATIONALLICENCE 700 1- Fu Shuxin Department of Gynecology and Obstetrics, Second Xiangya Hospital, Central South University, 410011, Changsha, Hunan, China aut NATIONALLICENCE 700 1- Li Na Department of Gynecology and Obstetrics, Second Xiangya Hospital, Central South University, 410011, Changsha, Hunan, China aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 284/3(2011-09-01), 773-778 0932-0067 284:3<773 2011 284 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer