caa a22 4500 445310316 CHVBK 20180317142627.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00404-010-1727-3 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1727-3 Fetal loss associated with second trimester amniocentesis [Elektronische Daten] [Somsri Pitukkijronnakorn, Patama Promsonthi, Panyu Panburana, Umaporn Udomsubpayakul, Apichart Chittacharoen] Objective: To evaluate the fetal loss rate associated with second trimester amniocentesis. Methods: All cases of pregnant women ≥35 years old with gestational age beyond 16weeks between 1997 and 2006 were included in this study. The study group consisted of all cases that the patients decided to have second trimester genetic amniocentesis. The control group was a randomized selection of pregnant women who refused any procedures. The ratio of the study case to the control case was 2:1. The fetal loss rates after amniocentesis before 24, and 28 complete weeks and the pregnancy outcome were analyzed. Results: 2,990 cases in the study group and 1,495 cases in the control group were used for this analysis. The mean maternal age in the study group and control group were 36.89±1.63 and 36.78±1.59years old, respectively (P=0.239). The procedure-related fetal loss before 24 and 28 complete weeks were 0.17 and 0.50%, respectively. The most common presenting symptom before fetal loss in the study cases was abdominal pain. Almost all of the cases leading to abortion had symptoms initiated after 48h post procedure. Significantly higher chances of abortion occurred in pregnant women ≥41years old (P=0.008). Conclusion: The procedure-related fetal loss rates in pregnant women ≥35 years old after amniocentesis before 24 and 28 complete weeks were 0.17 and 0.50%, respectively. The certain factors influencing the risk of fetal loss might be independent of the amniocentesis procedure. Springer-Verlag, 2010 Second trimester amniocentesis nationallicence Prenatal diagnosis nationallicence Fetal loss rate nationallicence Pitukkijronnakorn Somsri Maternal Fetal Medicine Unit, Department of Obstetrics and Gynaecology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, 10400, Bangkok, Thailand aut Promsonthi Patama Maternal Fetal Medicine Unit, Department of Obstetrics and Gynaecology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, 10400, Bangkok, Thailand aut Panburana Panyu Maternal Fetal Medicine Unit, Department of Obstetrics and Gynaecology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, 10400, Bangkok, Thailand aut Udomsubpayakul Umaporn Clinical Epidemiology Unit, Faculty of Medicine, Research Center, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand aut Chittacharoen Apichart Maternal Fetal Medicine Unit, Department of Obstetrics and Gynaecology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, 10400, Bangkok, Thailand aut Archives of Gynecology and Obstetrics Springer-Verlag 284/4(2011-10-01), 793-797 0932-0067 284:4<793 2011 284 404 https://doi.org/10.1007/s00404-010-1727-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1727-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pitukkijronnakorn Somsri Maternal Fetal Medicine Unit, Department of Obstetrics and Gynaecology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, 10400, Bangkok, Thailand aut NATIONALLICENCE 700 1- Promsonthi Patama Maternal Fetal Medicine Unit, Department of Obstetrics and Gynaecology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, 10400, Bangkok, Thailand aut NATIONALLICENCE 700 1- Panburana Panyu Maternal Fetal Medicine Unit, Department of Obstetrics and Gynaecology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, 10400, Bangkok, Thailand aut NATIONALLICENCE 700 1- Udomsubpayakul Umaporn Clinical Epidemiology Unit, Faculty of Medicine, Research Center, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand aut NATIONALLICENCE 700 1- Chittacharoen Apichart Maternal Fetal Medicine Unit, Department of Obstetrics and Gynaecology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, 10400, Bangkok, Thailand aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 284/4(2011-10-01), 793-797 0932-0067 284:4<793 2011 284 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer