caa a22 4500 445310324 CHVBK 20180317142627.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00404-010-1731-7 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1731-7 Cervical cytology of atypical squamous cells cannot exclude high-grade squamous intraepithelial lesion (ASC-H): histological results and recurrence after a loop electrosurgical excision procedure [Elektronische Daten] [P. Nogara, L. Manfroni, M. Consolaro] Objectives: To evaluate the histology of the loop electrosurgical excision procedure (LEEP) surgical tissues of patients with ASC-H and post-LEEP recurrence. Methods: Medical records of patients with ASC-H treated with LEEP between January 2004 and March 2008 in the town of União da Vitória, Paraná, seat of the Sixth Public Health Region of Paraná (CISVALI), were evaluated. The LEEP was carried out solely for ASC-H immediately after colposcopy, but without a histological diagnosis. Results: Most patients were less than 40years old (71.1%), with the largest group 20-39years old (p<0.0001). Twenty-eight patients (73.3%) showed histological lesions. Cervical intraepithelial neoplasias (CIN) I was present in 7 (18.4%), CIN II and CIN III in 9 (23.7%) each, microinvasive squamous cell carcinoma (SCMCA) in 2 (5.3%), and SCMCA plus in situ adenocarcinoma in 1 (2.2%). In 32 patients (84.2%), there was no involvement of the margins, including 100% with no dysplasia histology and CIN I, 80.0% of those with CIN II, and 88.9% of those with CIN III. Two patients (5.3%) had endocervical involvement, all of them with CIN II. Four patients (10.5%) had ectocervical and endocervical involvement, one of them with CIN III, and three of them with carcinomas. All patients with follow-up (+) were ASC-US, with no patients with dysplasia or CIN I. Conclusions: A very high portion of the women with ASC-H had lesions on post-LEEP histological examination, principally CIN II and III. These data show the benefits of treatment for ASC-H by LEEP immediately after colposcopy but without any previous histology. Springer-Verlag, 2010 Atypical squamous cell nationallicence ASC-H nationallicence LEEP nationallicence Histology nationallicence Recurrence nationallicence Nogara P. Division of Clinical Cytology, Clinical Analyses Department, Teaching and Research Laboratory of Clinical Analysis, State University of Maringá, Maringá, Paraná, Brazil aut Manfroni L. Sixth Region of Public Health of Paraná (CISVALI), Uniao da Vitoria, Paraná, Brazil aut Consolaro M. Division of Clinical Cytology, Clinical Analyses Department, Teaching and Research Laboratory of Clinical Analysis, State University of Maringá, Maringá, Paraná, Brazil aut Archives of Gynecology and Obstetrics Springer-Verlag 284/4(2011-10-01), 965-971 0932-0067 284:4<965 2011 284 404 https://doi.org/10.1007/s00404-010-1731-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1731-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nogara P. Division of Clinical Cytology, Clinical Analyses Department, Teaching and Research Laboratory of Clinical Analysis, State University of Maringá, Maringá, Paraná, Brazil aut NATIONALLICENCE 700 1- Manfroni L. Sixth Region of Public Health of Paraná (CISVALI), Uniao da Vitoria, Paraná, Brazil aut NATIONALLICENCE 700 1- Consolaro M. Division of Clinical Cytology, Clinical Analyses Department, Teaching and Research Laboratory of Clinical Analysis, State University of Maringá, Maringá, Paraná, Brazil aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 284/4(2011-10-01), 965-971 0932-0067 284:4<965 2011 284 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer