caa a22 4500 445310332 CHVBK 20180317142627.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00404-010-1743-3 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1743-3 The association between dietary intake and cervical intraepithelial neoplasia grade 2 or higher among women in a high-risk rural area of china [Elektronische Daten] [Chang-Yan Feng, Margaret Lin, Divya Lakhaney, Hai-Kui Sun, Xing-Bi Dai, Fang-Hui Zhao, You-Lin Qiao] Objective: To evaluate the relationship between dietary intake and risk of cervical intraepithelial neoplasia grade 2 or higher (CIN2+) while controlling for human papillomavirus (HPV) infection. Methods: In 1999 and 2002, 11,031 women aged 35-50, were screened as part of two cross-sectional population-based cervical cancer screening studies in China. Dietary food intake information was collected by a 79-item Food Frequency Questionnaire (FFQ). 748 HPV-positive women (557 normal biopsy; 95 CIN2, 79 CIN3 and 17 cancer) with completed interviews and biopsy results were included in our data analysis. Specific dietary food groups were classified into dark-colored vegetables, light-colored vegetables, onion vegetables, legumes, nuts, eggs, and meat. Unconditional logistic regression was used to evaluate the association between dietary intake and the risk of developing CIN2+. Results: Inverse associations between CIN2+ risk and onion vegetables, legumes, nuts, and meat were observed. Comparison of the lowest and highest tertiles for consumption of onion vegetables, legumes, nuts, and meat yielded adjusted odds ratios (ORs) of 0.589 [95% confidence intervals (CI), 0.387-0.897; P for trend=0.011], 0.591 (95% CI, 0.392-0.892; P for trend=0.012), 0.635 (95% CI, 0.426-0.946; P for trend=0.019), 0.624 (95% CI, 0.406-0.958; P for trend=0.044), respectively, for CIN2+ risk among 748 HPV-positive women. No associations were found between CIN2+ risk and dark-colored vegetables, light-colored vegetables or eggs. Conclusions: Dietary intake of onion vegetables, legumes, nuts, and meat is associated with reduced risk of CIN2+. These foods may provide a protective factor against CIN2+. Springer-Verlag, 2010 Cervical intraepithelial neoplasia nationallicence HPV nationallicence Diet nationallicence China nationallicence Feng Chang-Yan School of Public Health, Chongqing Medical University, 1 Yi Xue Yuan Road, 400016, Chongqing, People's Republic of China aut Lin Margaret School of Medicine, Washington University in St. Louis, 550 S. Euclid Ave, 63110, St. Louis, MO, USA aut Lakhaney Divya School of Medicine, New York University, 10016, New York, NY, USA aut Sun Hai-Kui Department of Cancer Epidemiology, Cancer Institute, Chinese Academy of Medical Sciences, 17 South. Panjiayuan Lane, 100021, Beijing, People's Republic of China aut Dai Xing-Bi School of Public Health, Chongqing Medical University, 1 Yi Xue Yuan Road, 400016, Chongqing, People's Republic of China aut Zhao Fang-Hui Department of Cancer Epidemiology, Cancer Institute, Chinese Academy of Medical Sciences, 17 South. Panjiayuan Lane, 100021, Beijing, People's Republic of China aut Qiao You-Lin Department of Cancer Epidemiology, Cancer Institute, Chinese Academy of Medical Sciences, 17 South. Panjiayuan Lane, 100021, Beijing, People's Republic of China aut Archives of Gynecology and Obstetrics Springer-Verlag 284/4(2011-10-01), 973-980 0932-0067 284:4<973 2011 284 404 https://doi.org/10.1007/s00404-010-1743-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1743-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Feng Chang-Yan School of Public Health, Chongqing Medical University, 1 Yi Xue Yuan Road, 400016, Chongqing, People's Republic of China aut NATIONALLICENCE 700 1- Lin Margaret School of Medicine, Washington University in St. Louis, 550 S. Euclid Ave, 63110, St. Louis, MO, USA aut NATIONALLICENCE 700 1- Lakhaney Divya School of Medicine, New York University, 10016, New York, NY, USA aut NATIONALLICENCE 700 1- Sun Hai-Kui Department of Cancer Epidemiology, Cancer Institute, Chinese Academy of Medical Sciences, 17 South. Panjiayuan Lane, 100021, Beijing, People's Republic of China aut NATIONALLICENCE 700 1- Dai Xing-Bi School of Public Health, Chongqing Medical University, 1 Yi Xue Yuan Road, 400016, Chongqing, People's Republic of China aut NATIONALLICENCE 700 1- Zhao Fang-Hui Department of Cancer Epidemiology, Cancer Institute, Chinese Academy of Medical Sciences, 17 South. Panjiayuan Lane, 100021, Beijing, People's Republic of China aut NATIONALLICENCE 700 1- Qiao You-Lin Department of Cancer Epidemiology, Cancer Institute, Chinese Academy of Medical Sciences, 17 South. Panjiayuan Lane, 100021, Beijing, People's Republic of China aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 284/4(2011-10-01), 973-980 0932-0067 284:4<973 2011 284 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer