caa a22 4500 445310383 CHVBK 20180317142627.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00404-011-1950-6 doi (NATIONALLICENCE)springer-10.1007/s00404-011-1950-6 Timing of intrauterine insemination: an attempt to unravel the enigma [Elektronische Daten] [Syed Rahman, Debjyoti Karmakar, Neena Malhotra, Sunesh Kumar] Introduction: Controlled ovarian stimulation (COS) with intrauterine insemination (IUI) is an effective treatment in cases of cervical factor, unexplained infertility and mild male factor. The optimal timing of IUI after human chorionic gonadotrophin (hCG) after COS with clomiphene citrate is debatable and may be a factor limiting success of same. This study was designed to scientifically determine if variation in the timing of IUI could affect the cycle outcome. Materials and methods: In a prospective randomized trial couples with mild male factor, unexplained infertility and mild endometriosis who underwent COS with IUI were recruited. COS was achieved with clomiphene citrate. Two hundred and four women underwent 461 cycles of IUI. Women were randomized to two groups: group I (104 patients, 231 cycles) had IUI 36h after hCG, while group II (100 patients, 230 cycles) had IUI 24h after hCG. Primary outcome included pregnancy rate per couple and per cycle. Results: Fifty-four patients had pregnancy with and pregnancy rate per couple and per cycle were 32.6 and 14.7% in group I and 20 and 8.6% in group II, respectively (not statistically different). Conclusions: Altering timing of IUI after COS does not enhance pregnancy rates. IUI 36h after hCG has marginally better pregnancy rates than 24h. Timing of insemination may be kept at 24 or 36h after hCG injection to suit the convenience of the clinic or care provider. The lack of statistical significance indicates need for larger studies to draw guidelines. Springer-Verlag, 2011 Insemination nationallicence Infertility nationallicence Timing nationallicence Rahman Syed Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, 110029, New Delhi, India aut Karmakar Debjyoti Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, 110029, New Delhi, India aut Malhotra Neena Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, 110029, New Delhi, India aut Kumar Sunesh Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, 110029, New Delhi, India aut Archives of Gynecology and Obstetrics Springer-Verlag 284/4(2011-10-01), 1023-1027 0932-0067 284:4<1023 2011 284 404 https://doi.org/10.1007/s00404-011-1950-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-011-1950-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rahman Syed Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, 110029, New Delhi, India aut NATIONALLICENCE 700 1- Karmakar Debjyoti Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, 110029, New Delhi, India aut NATIONALLICENCE 700 1- Malhotra Neena Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, 110029, New Delhi, India aut NATIONALLICENCE 700 1- Kumar Sunesh Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, 110029, New Delhi, India aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 284/4(2011-10-01), 1023-1027 0932-0067 284:4<1023 2011 284 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer