caa a22 4500 445310421 CHVBK 20180317142627.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00404-010-1790-9 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1790-9 Alteration of cardiovascular risk parameters in women with polycystic ovary syndrome who were prescribed to ethinyl estradiol-cyproterone acetate [Elektronische Daten] [Funda Gode, Cigdem Karagoz, Cemal Posaci, Bahadir Saatli, Didem Uysal, Mustafa Secil, Bahri Akdeniz] Purpose: We aimed to evaluate the alteration of cardiovascular and metabolic risk parameters of polycystic ovary syndrome (PCOS) patients after a 6-month treatment with an oral contraceptive (OC) containing cyproterone acetate (CPA). Methods: Forty women with PCOS were evaluated at baseline and after treatment with an OC. Carotid intima-media thickness (CIMT), brachial artery flow-mediated dilatation (FMD), nitrate-mediated dilatation (NMD), high sensitive (hs)-CRP, lipid levels, index of glucose sensitivity, and homeostasis model assessment of insulin resistance index (HOMA) were assessed. Results: Mean CIMT was significantly elevated (0.03±0.01mm) (p<0.05). There was a tendency of reduction in FMD, which was significant among overweight patients (p<0.05). Total cholesterol, low-density lipid (LDL), and triglyceride levels were significantly elevated (p<0.05). Conclusion: CIMT as an indicator of early atherosclerosis and FMD as a finding of endothelial dysfunction seem to be deteriorated especially in overweight PCOS patients who were prescribed to OC containing cyproterone acetate for 6months. Springer-Verlag, 2010 Polycystic ovary syndrome nationallicence Cardiovascular risk nationallicence Oral contraceptives nationallicence Metabolic risk nationallicence Gode Funda Department of Obstetrics and Gynecology, Dokuz Eylul University Medical School, Dokuz Eylul University Hospital, 35210, Balcova, Izmir, Turkey aut Karagoz Cigdem Department of Radiology, Dokuz Eylul University Medical School, Izmir, Turkey aut Posaci Cemal Department of Obstetrics and Gynecology, Dokuz Eylul University Medical School, Dokuz Eylul University Hospital, 35210, Balcova, Izmir, Turkey aut Saatli Bahadir Department of Obstetrics and Gynecology, Dokuz Eylul University Medical School, Dokuz Eylul University Hospital, 35210, Balcova, Izmir, Turkey aut Uysal Didem Department of Obstetrics and Gynecology, Dokuz Eylul University Medical School, Dokuz Eylul University Hospital, 35210, Balcova, Izmir, Turkey aut Secil Mustafa Department of Radiology, Dokuz Eylul University Medical School, Izmir, Turkey aut Akdeniz Bahri Department of Cardiology, Dokuz Eylul University Medical School, Izmir, Turkey aut Archives of Gynecology and Obstetrics Springer-Verlag 284/4(2011-10-01), 923-929 0932-0067 284:4<923 2011 284 404 https://doi.org/10.1007/s00404-010-1790-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1790-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gode Funda Department of Obstetrics and Gynecology, Dokuz Eylul University Medical School, Dokuz Eylul University Hospital, 35210, Balcova, Izmir, Turkey aut NATIONALLICENCE 700 1- Karagoz Cigdem Department of Radiology, Dokuz Eylul University Medical School, Izmir, Turkey aut NATIONALLICENCE 700 1- Posaci Cemal Department of Obstetrics and Gynecology, Dokuz Eylul University Medical School, Dokuz Eylul University Hospital, 35210, Balcova, Izmir, Turkey aut NATIONALLICENCE 700 1- Saatli Bahadir Department of Obstetrics and Gynecology, Dokuz Eylul University Medical School, Dokuz Eylul University Hospital, 35210, Balcova, Izmir, Turkey aut NATIONALLICENCE 700 1- Uysal Didem Department of Obstetrics and Gynecology, Dokuz Eylul University Medical School, Dokuz Eylul University Hospital, 35210, Balcova, Izmir, Turkey aut NATIONALLICENCE 700 1- Secil Mustafa Department of Radiology, Dokuz Eylul University Medical School, Izmir, Turkey aut NATIONALLICENCE 700 1- Akdeniz Bahri Department of Cardiology, Dokuz Eylul University Medical School, Izmir, Turkey aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 284/4(2011-10-01), 923-929 0932-0067 284:4<923 2011 284 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer