caa a22 4500 445310464 CHVBK 20180317142627.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00404-010-1779-4 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1779-4 Effects of three Kampo formulae: Tokishakuyakusan (TJ-23), Kamishoyosan (TJ-24), and Keishibukuryogan (TJ-25) on Japanese peri- and postmenopausal women with sleep disturbances [Elektronische Daten] [Masakazu Terauchi, Shiro Hiramitsu, Mihoko Akiyoshi, Yoko Owa, Kiyoko Kato, Satoshi Obayashi, Eisuke Matsushima, Toshiro Kubota] Purpose: To assess the effects of Kampo, a traditional Japanese adaptation of Chinese herbal medicine, on peri- and postmenopausal women with sleep disturbances. Methods: Among the records of 1,523 peri- and postmenopausal women who are enrolled in the Health and Nutrition Education Program at the Tokyo Medical and Dental University, Menopause Clinic, during 1995-2009, about 151 women suffering from moderate to severe sleep disturbances were retrospectively analyzed. These women had received only health/nutrition education (control; n=77) or received treatment with one of the three major Kampo formulae: Tokishakuyakusan (TJ-23; n=42), Kamishoyosan (TJ-24; n=16), or Keishibukuryogan (TJ-25; n=16) according to their "Sho” or symptom patterns. Subjective sleep parameters, menopausal symptoms, health-related quality of life, body composition, blood pressure, and pulse rate were compared before and after the intervention. Results: The TJ-25 group had significantly higher body weight, body mass index, body fat, lean body mass, resting energy expenditure, and relatively high blood pressure and heart rate at baseline than the other groups. After ~5-month follow up, TJ-23 reduced the sleep disruption frequency, increased lean body mass, and decreased diastolic pressure. TJ-24 alleviated subjective sleep disturbances; improved difficulties in initiating sleep, disrupted sleep, and non-restorative sleep; and relieved headache/dizziness. TJ-25 improved subjective sleep disturbances, alleviated perspiration, and reduced systolic/diastolic pressure and heart rate. Conclusions: Each of the Kampo formulae effectively alleviated sleep disturbances in Japanese peri- and postmenopausal women. Middle-aged female patients having sleeping disorder could successfully be treated using Kampo medicines. Springer-Verlag, 2010 Menopause nationallicence Sleep initiation and maintenance disorders nationallicence Herbal medicine nationallicence Complementary therapies nationallicence East Asian traditional medicine nationallicence Kampo medicine nationallicence Terauchi Masakazu Department of Obstetrics and Gynecology, Tokyo Medical and Dental University, Yushima 1-5-45, 113-8510, Bunkyo, Tokyo, Japan aut Hiramitsu Shiro Department of Obstetrics and Gynecology, Tokyo Medical and Dental University, Yushima 1-5-45, 113-8510, Bunkyo, Tokyo, Japan aut Akiyoshi Mihoko Department of Obstetrics and Gynecology, Tokyo Medical and Dental University, Yushima 1-5-45, 113-8510, Bunkyo, Tokyo, Japan aut Owa Yoko Department of Obstetrics and Gynecology, Tokyo Medical and Dental University, Yushima 1-5-45, 113-8510, Bunkyo, Tokyo, Japan aut Kato Kiyoko Department of Obstetrics and Gynecology, Tokyo Medical and Dental University, Yushima 1-5-45, 113-8510, Bunkyo, Tokyo, Japan aut Obayashi Satoshi Department of Obstetrics and Gynecology, Tokyo Medical and Dental University, Yushima 1-5-45, 113-8510, Bunkyo, Tokyo, Japan aut Matsushima Eisuke Department of Psychosomatics, Tokyo Medical and Dental University, Yushima 1-5-45, 113-8510, Bunkyo, Tokyo, Japan aut Kubota Toshiro Department of Obstetrics and Gynecology, Tokyo Medical and Dental University, Yushima 1-5-45, 113-8510, Bunkyo, Tokyo, Japan aut Archives of Gynecology and Obstetrics Springer-Verlag 284/4(2011-10-01), 913-921 0932-0067 284:4<913 2011 284 404 https://doi.org/10.1007/s00404-010-1779-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1779-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Terauchi Masakazu Department of Obstetrics and Gynecology, Tokyo Medical and Dental University, Yushima 1-5-45, 113-8510, Bunkyo, Tokyo, Japan aut NATIONALLICENCE 700 1- Hiramitsu Shiro Department of Obstetrics and Gynecology, Tokyo Medical and Dental University, Yushima 1-5-45, 113-8510, Bunkyo, Tokyo, Japan aut NATIONALLICENCE 700 1- Akiyoshi Mihoko Department of Obstetrics and Gynecology, Tokyo Medical and Dental University, Yushima 1-5-45, 113-8510, Bunkyo, Tokyo, Japan aut NATIONALLICENCE 700 1- Owa Yoko Department of Obstetrics and Gynecology, Tokyo Medical and Dental University, Yushima 1-5-45, 113-8510, Bunkyo, Tokyo, Japan aut NATIONALLICENCE 700 1- Kato Kiyoko Department of Obstetrics and Gynecology, Tokyo Medical and Dental University, Yushima 1-5-45, 113-8510, Bunkyo, Tokyo, Japan aut NATIONALLICENCE 700 1- Obayashi Satoshi Department of Obstetrics and Gynecology, Tokyo Medical and Dental University, Yushima 1-5-45, 113-8510, Bunkyo, Tokyo, Japan aut NATIONALLICENCE 700 1- Matsushima Eisuke Department of Psychosomatics, Tokyo Medical and Dental University, Yushima 1-5-45, 113-8510, Bunkyo, Tokyo, Japan aut NATIONALLICENCE 700 1- Kubota Toshiro Department of Obstetrics and Gynecology, Tokyo Medical and Dental University, Yushima 1-5-45, 113-8510, Bunkyo, Tokyo, Japan aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 284/4(2011-10-01), 913-921 0932-0067 284:4<913 2011 284 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer