caa a22 4500 445310502 CHVBK 20180317142628.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00404-010-1777-6 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1777-6 Radiotherapy for Japanese elderly patients with cervical cancer: preliminary survival outcomes and evaluation of treatment-related toxicity [Elektronische Daten] [Kenji Yoshida, Ryohei Sasaki, Hideki Nishimura, Daisuke Miyawaki, Tetsuya Kawabe, Yoshiaki Okamoto, Koji Nakabayashi, Shigeki Yoshida, Kazuro Sugimura] Purpose: To examine the preliminary survival outcomes and treatment-related toxicity for elderly patients with cervical cancer treated with radiotherapy (RT). Methods: Forty patients ≥75years old with cervical cancer who were treated with RT were evaluated. Of these 40 patients, 25 were classified as FIGO stage I or II and 15 as stage III or IVA. Thirty-five patients were treated with radical RT (RRT), and five were treated with surgery plus adjuvant RT (S+ART). External beam radiotherapy combined with high-dose-rate intracavitary brachytherapy was performed on 31 patients who were treated with RRT and on 2 patients who were treated with S+ART because of positive vaginal surgical margins. The patients' median age was 78years (range 75-89years). Concurrent chemotherapy (CCT) was performed on five patients (RRT: 3, S+ART: 2). Results: The median follow-up period was 20months (range 1-85months). Only one patient could not complete RT. The 3-year overall and disease-specific survival (OS and DSS) rates for all patients were 58 and 80%, respectively. Five patients experienced Grade 3 acute toxicity; two were treated with RRT (2/35), and three were treated with S+ART (3/5, 2 of them with CCT). Two patients experienced Grade 3 late toxicity; one was treated with RRT (1/35, with CCT) and the other was treated with S+ART (1/5). No Grade 4 or higher toxicity was experienced. Conclusions: RRT for elderly patients with cervical cancer is generally effective and safe, but severe toxicity may occur with more aggressive treatment modalities. The Author(s), 2010 Cervical cancer nationallicence Radiotherapy nationallicence Elderly patients nationallicence Treatment-related toxicity nationallicence Yoshida Kenji Department of Radiation Oncology, Kobe University Graduate School of Medicine, 7-5-2 Kusunokicho, Chuouku, 650-0017, Kobe City, Hyogo, Japan aut Sasaki Ryohei Department of Radiation Oncology, Kobe University Graduate School of Medicine, 7-5-2 Kusunokicho, Chuouku, 650-0017, Kobe City, Hyogo, Japan aut Nishimura Hideki Department of Radiation Oncology, Kobe University Graduate School of Medicine, 7-5-2 Kusunokicho, Chuouku, 650-0017, Kobe City, Hyogo, Japan aut Miyawaki Daisuke Department of Radiation Oncology, Kobe University Graduate School of Medicine, 7-5-2 Kusunokicho, Chuouku, 650-0017, Kobe City, Hyogo, Japan aut Kawabe Tetsuya Department of Radiology, Dokkyou Medical University, Tochigi, Japan aut Okamoto Yoshiaki Department of Radiology, Osaka Police Hospital, Osaka, Japan aut Nakabayashi Koji Department of Gynecology, Kobe University Graduate School of Medicine, Kobe City, Hyogo, Japan aut Yoshida Shigeki Department of Gynecology, Kobe University Graduate School of Medicine, Kobe City, Hyogo, Japan aut Sugimura Kazuro Department of Radiology, Kobe University Graduate School of Medicine, Kobe City, Hyogo, Japan aut Archives of Gynecology and Obstetrics Springer-Verlag 284/4(2011-10-01), 1007-1014 0932-0067 284:4<1007 2011 284 404 https://doi.org/10.1007/s00404-010-1777-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1777-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yoshida Kenji Department of Radiation Oncology, Kobe University Graduate School of Medicine, 7-5-2 Kusunokicho, Chuouku, 650-0017, Kobe City, Hyogo, Japan aut NATIONALLICENCE 700 1- Sasaki Ryohei Department of Radiation Oncology, Kobe University Graduate School of Medicine, 7-5-2 Kusunokicho, Chuouku, 650-0017, Kobe City, Hyogo, Japan aut NATIONALLICENCE 700 1- Nishimura Hideki Department of Radiation Oncology, Kobe University Graduate School of Medicine, 7-5-2 Kusunokicho, Chuouku, 650-0017, Kobe City, Hyogo, Japan aut NATIONALLICENCE 700 1- Miyawaki Daisuke Department of Radiation Oncology, Kobe University Graduate School of Medicine, 7-5-2 Kusunokicho, Chuouku, 650-0017, Kobe City, Hyogo, Japan aut NATIONALLICENCE 700 1- Kawabe Tetsuya Department of Radiology, Dokkyou Medical University, Tochigi, Japan aut NATIONALLICENCE 700 1- Okamoto Yoshiaki Department of Radiology, Osaka Police Hospital, Osaka, Japan aut NATIONALLICENCE 700 1- Nakabayashi Koji Department of Gynecology, Kobe University Graduate School of Medicine, Kobe City, Hyogo, Japan aut NATIONALLICENCE 700 1- Yoshida Shigeki Department of Gynecology, Kobe University Graduate School of Medicine, Kobe City, Hyogo, Japan aut NATIONALLICENCE 700 1- Sugimura Kazuro Department of Radiology, Kobe University Graduate School of Medicine, Kobe City, Hyogo, Japan aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 284/4(2011-10-01), 1007-1014 0932-0067 284:4<1007 2011 284 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer