caa a22 4500 445310537 CHVBK 20180317142628.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00404-010-1759-8 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1759-8 Role of Helicobacter pylori in the pathogenesis of hyperemesis gravidarum [Elektronische Daten] [Ghada Mansour, Ehab Nashaat] Purpose: To evaluate the role of Helicobacter pylori (H. pylori) in the pathogenesis of hyperemesis gravidarum (HG) and the value of adding a non teratogenic regimen for its treatment in intractable cases. Methods: Eighty hyperemesis gravidarum cases were recruited from Ain Shams University out patient clinics. A complete history was taken including history of medical disorders and chronic medications intake as non steroidal anti-inflammatory drugs. After general and local examination, ultrasound was done for all cases to exclude obstetric causes of hyperemesis. Eighty normal pregnant women acted as control. Serum test for H. pylori IgG antibody titre was done for all patients and controls. Results: Seventy-one cases among the 80 HG cases and twenty-four out of the 80 controls were H. pylori positive. Eight HG cases developed severe intractable vomiting. Three of them developed attacks of hematemesis. Gastroscopy done for the eight cases revealed antral gastritis and duodenitis. Gastric and duodenal erosions were found in two cases. The eight patients received a non teratogenic regimen for treatment. Attacks of vomiting decreased and pregnancy continued till delivery of healthy newborns. Conclusion: Screening for H. pylori should be added to the investigations of hyperemesis gravidarum cases. Non teratogenic treatment can be considered in intractable cases. Springer-Verlag, 2010 Helicobacter pylori nationallicence Hyperemesis gravidarum nationallicence Mansour Ghada Department of Obstetrics and Gynecology, Ain Shams University, 5th El Gahez street, Seventh area, Nasr city, Cairo, Egypt aut Nashaat Ehab Department of Internal Medicine, Ain Shams University, Cairo, Egypt aut Archives of Gynecology and Obstetrics Springer-Verlag 284/4(2011-10-01), 843-847 0932-0067 284:4<843 2011 284 404 https://doi.org/10.1007/s00404-010-1759-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1759-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mansour Ghada Department of Obstetrics and Gynecology, Ain Shams University, 5th El Gahez street, Seventh area, Nasr city, Cairo, Egypt aut NATIONALLICENCE 700 1- Nashaat Ehab Department of Internal Medicine, Ain Shams University, Cairo, Egypt aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 284/4(2011-10-01), 843-847 0932-0067 284:4<843 2011 284 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer