caa a22 4500 445310596 CHVBK 20180317142628.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00404-010-1756-y doi (NATIONALLICENCE)springer-10.1007/s00404-010-1756-y The association between inherited thrombophilias and pregnancy-related hypertension recurrence [Elektronische Daten] [Inanc Mendilcioglu, Turker Bilgen, Yunus Arikan, Ibrahim Keser, Mehmet Simsek, Aysen Timuragaoglu] Purpose: The aim of this study was to determine the association between inherited thrombophilias and pregnancy-related hypertension recurrence. Methods: In this case-control study, blood samples were obtained from patients who had at least two pregnancies complicated with pregnancy-related hypertension (n=41) and healthy, normotensive pregnancies delivered without any complication (n=38). Following the DNA extraction, samples were tested for factor V Leiden, prothrombin G20210A and homozygous methylene tetrahydrofolate reductase (MTHFR) C677T mutations using reverse hybridization method. Results: Common inherited thrombophilias were present in 26.8% of women with recurrent pregnancy-related hypertension group and 23.7% of control subjects (odds ratio 1.1; 95% confidence interval, 0.6-1.9). No significant difference was observed between two groups in terms of factor V Leiden, prothrombin G20210A and MTHFR C677T mutations. Conclusion: Our data suggest that factor V Leiden, prothrombin G20210A and MTHFR C677T mutations are not associated with pregnancy-related hypertension recurrence. Springer-Verlag, 2010 Factor V Leiden nationallicence Inherited thrombophilia nationallicence Preeclampsia nationallicence Pregnancy-related hypertension nationallicence Prothrombin G20210A nationallicence Mendilcioglu Inanc Department of Obstetrics and Gynecology, School of Medicine, Akdeniz University, Dumlupinar Boulevard, 07070, Antalya, Turkey aut Bilgen Turker Department of Medical Genetics, School of Medicine, Akdeniz University, Antalya, Turkey aut Arikan Yunus Department of Medical Genetics, School of Medicine, Akdeniz University, Antalya, Turkey aut Keser Ibrahim Department of Medical Genetics, School of Medicine, Akdeniz University, Antalya, Turkey aut Simsek Mehmet Department of Obstetrics and Gynecology, School of Medicine, Akdeniz University, Dumlupinar Boulevard, 07070, Antalya, Turkey aut Timuragaoglu Aysen Department of Hematology, School of Medicine, Akdeniz University, Antalya, Turkey aut Archives of Gynecology and Obstetrics Springer-Verlag 284/4(2011-10-01), 837-841 0932-0067 284:4<837 2011 284 404 https://doi.org/10.1007/s00404-010-1756-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1756-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mendilcioglu Inanc Department of Obstetrics and Gynecology, School of Medicine, Akdeniz University, Dumlupinar Boulevard, 07070, Antalya, Turkey aut NATIONALLICENCE 700 1- Bilgen Turker Department of Medical Genetics, School of Medicine, Akdeniz University, Antalya, Turkey aut NATIONALLICENCE 700 1- Arikan Yunus Department of Medical Genetics, School of Medicine, Akdeniz University, Antalya, Turkey aut NATIONALLICENCE 700 1- Keser Ibrahim Department of Medical Genetics, School of Medicine, Akdeniz University, Antalya, Turkey aut NATIONALLICENCE 700 1- Simsek Mehmet Department of Obstetrics and Gynecology, School of Medicine, Akdeniz University, Dumlupinar Boulevard, 07070, Antalya, Turkey aut NATIONALLICENCE 700 1- Timuragaoglu Aysen Department of Hematology, School of Medicine, Akdeniz University, Antalya, Turkey aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 284/4(2011-10-01), 837-841 0932-0067 284:4<837 2011 284 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer