caa a22 4500 445310618 CHVBK 20180317142628.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00404-010-1762-0 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1762-0 Seasonality of spina bifida in Northern Germany [Elektronische Daten] [D. Beyer, K. Diedrich, J. Weichert, A. Kavallaris, F. Amari] Purpose: To verify a seasonal variation in the incidence of spina bifida and thus to identify possible environmental triggers leading to its developement. Methods: An interdisciplinary approach has been taken to develop a better understanding of spina bifida through collaborative efforts from investigators specializing in genetics, fetal pathology, paediatrics, neuro-surgery and prenatal ultrasonographic diagnosis. All pregnancies with fetal spina bifida were retrospectively analyzed from May 1 1993 through May 1 2010 at Luebeck University Fetal Health Center. Results were used to construct a model to predict the occurrence of fetal spina bifida based on seasonal variation and environmental influence reflected by climatic changes and environmental pollution. Furthermore, data were categorized in respect to the date of conception and subdivided into date of conception during summer (April-September) and winter months (October-March). Results: Neither a seasonal distribution of conception for fetuses with spina bifida in the defined time frame could be verified nor a relevant influence of the analyzed environmental factors on the prevalence of spina bifida could be proved. The incidence of spina bifida has remained relatively stable within the last 17years at 2.5 per 1,000 screened pregnancies. Conclusion: Since we were unable to demonstrate a relationship between seasonal variation and certain environmental factors on the incidence of fetal spina bifida, other factors should be investigated for a possible association with the onset of fetal spina bifida. Springer-Verlag, 2010 Spina bifida nationallicence Environmental influence nationallicence Birth defect nationallicence Development nationallicence Beyer D. Department of Obstetrics and Gynaecology, Schleswig-Holstein University, Campus Luebeck, Ratzeburger Allee 160, 23538, Luebeck, Germany aut Diedrich K. Department of Obstetrics and Gynaecology, Schleswig-Holstein University, Campus Luebeck, Ratzeburger Allee 160, 23538, Luebeck, Germany aut Weichert J. Department of Obstetrics and Gynaecology, Schleswig-Holstein University, Campus Luebeck, Ratzeburger Allee 160, 23538, Luebeck, Germany aut Kavallaris A. Department of Obstetrics and Gynaecology, Schleswig-Holstein University, Campus Luebeck, Ratzeburger Allee 160, 23538, Luebeck, Germany aut Amari F. Department of Obstetrics and Gynaecology, Schleswig-Holstein University, Campus Luebeck, Ratzeburger Allee 160, 23538, Luebeck, Germany aut Archives of Gynecology and Obstetrics Springer-Verlag 284/4(2011-10-01), 849-854 0932-0067 284:4<849 2011 284 404 https://doi.org/10.1007/s00404-010-1762-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1762-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Beyer D. Department of Obstetrics and Gynaecology, Schleswig-Holstein University, Campus Luebeck, Ratzeburger Allee 160, 23538, Luebeck, Germany aut NATIONALLICENCE 700 1- Diedrich K. Department of Obstetrics and Gynaecology, Schleswig-Holstein University, Campus Luebeck, Ratzeburger Allee 160, 23538, Luebeck, Germany aut NATIONALLICENCE 700 1- Weichert J. Department of Obstetrics and Gynaecology, Schleswig-Holstein University, Campus Luebeck, Ratzeburger Allee 160, 23538, Luebeck, Germany aut NATIONALLICENCE 700 1- Kavallaris A. Department of Obstetrics and Gynaecology, Schleswig-Holstein University, Campus Luebeck, Ratzeburger Allee 160, 23538, Luebeck, Germany aut NATIONALLICENCE 700 1- Amari F. Department of Obstetrics and Gynaecology, Schleswig-Holstein University, Campus Luebeck, Ratzeburger Allee 160, 23538, Luebeck, Germany aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 284/4(2011-10-01), 849-854 0932-0067 284:4<849 2011 284 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer