caa a22 4500 445310669 CHVBK 20180317142628.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00404-010-1725-5 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1725-5 Synchronous ovarian endometrioid adenocarcinoma with a functioning stroma and endometrial endometrioid adenocarcinoma by different loss of heterozygosity findings [Elektronische Daten] [Noriyuki Takai, Kentaro Kai, Akitoshi Tsuno, Kaei Nasu, Kenji Kashima, Hisashi Narahara] Purpose: Mucinous epithelial ovarian tumors generally have estrogenic stroma, although the frequency of endometrioid adenocarcinoma with functioning stroma is very low. And while synchronous development of carcinomas in the endometrium and ovaries is a fairly common phenomenon, the distinction of a single clonal tumor with metastasis from two independent primary tumors may present a diagnostic challenge. We present a rare case of a 31-year-old woman with endometrioid adenocarcinoma of the ovary with functioning stroma and endometrial endometrioid adenocarcinoma who showed symptoms of virilization. Her preoperative levels of serum testosterone and estradiol were as high as 553ng/dL and 177pg/mL, respectively, and her serum gonadotropin levels were suppressed. After surgery, the serum levels of testosterone and estradiol decreased and that of follicle-stimulating hormone increased. Methods: To develop a mean of differentiating a single tumor with metastasis from synchronous primary ovarian and endometrial cancers, we performed a microsatellite analysis. Twenty-five dinucleotide microsatellite markers were selected, and microsatellite analysis was performed by a high-resolution method using fluorescence-labeled polymerase chain reaction and laser scanning. Results: In this case, both ovarian carcinoma and endometrial carcinoma demonstrated loss of heterozygosity (LOH). However, the LOH findings of the ovarian tumor and endometrial tumor were different. Conclusions: Loss of heterozygosity analysis may be helpful to differentiate synchronous primary ovarian and endometrial cancers from a single tumor with metastasis. Springer-Verlag, 2010 Synchronous primary ovarian and endometrial cancer nationallicence Functioning stroma nationallicence Virilization nationallicence Microsatellite instability nationallicence Takai Noriyuki Department of Obstetrics and Gynecology, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, 879-5593, Yufu, Oita, Japan aut Kai Kentaro Department of Obstetrics and Gynecology, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, 879-5593, Yufu, Oita, Japan aut Tsuno Akitoshi Department of Obstetrics and Gynecology, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, 879-5593, Yufu, Oita, Japan aut Nasu Kaei Department of Obstetrics and Gynecology, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, 879-5593, Yufu, Oita, Japan aut Kashima Kenji Department of Pathology, Oita University Faculty of Medicine, Yufu, Oita, Japan aut Narahara Hisashi Department of Obstetrics and Gynecology, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, 879-5593, Yufu, Oita, Japan aut Archives of Gynecology and Obstetrics Springer-Verlag 284/4(2011-10-01), 951-955 0932-0067 284:4<951 2011 284 404 https://doi.org/10.1007/s00404-010-1725-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1725-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Takai Noriyuki Department of Obstetrics and Gynecology, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, 879-5593, Yufu, Oita, Japan aut NATIONALLICENCE 700 1- Kai Kentaro Department of Obstetrics and Gynecology, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, 879-5593, Yufu, Oita, Japan aut NATIONALLICENCE 700 1- Tsuno Akitoshi Department of Obstetrics and Gynecology, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, 879-5593, Yufu, Oita, Japan aut NATIONALLICENCE 700 1- Nasu Kaei Department of Obstetrics and Gynecology, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, 879-5593, Yufu, Oita, Japan aut NATIONALLICENCE 700 1- Kashima Kenji Department of Pathology, Oita University Faculty of Medicine, Yufu, Oita, Japan aut NATIONALLICENCE 700 1- Narahara Hisashi Department of Obstetrics and Gynecology, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, 879-5593, Yufu, Oita, Japan aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 284/4(2011-10-01), 951-955 0932-0067 284:4<951 2011 284 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer