caa a22 4500 445310677 CHVBK 20180317142628.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00404-010-1751-3 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1751-3 Nifedipine for the treatment of preterm labor in twin and singleton pregnancies [Elektronische Daten] [Aysel Derbent, Serap Simavli, İlknur Gümüş, M. Tatli, Nilgün Turhan] Purpose: To investigate the outcomes of singleton and twin pregnancies that were complicated by spontaneous preterm labor and received nifedipine tocolysis. Methods: We identified the following subjects from a computerized, hospital database: 58 singleton and 32 twin pregnancies that were between 24 and 34 weeks of gestation, admitted for spontaneous preterm labor without rupture of the membranes, and receiving tocolysis with nifedipine. Data were analyzed using the Chi-square test, the Mann-Whitney test, and the Kaplan-Meier survival analysis. Results: Spontaneous, preterm delivery occurred in 31.1% cases of singleton and 81.3% of twin pregnancies. Although the 22% of the mothers of twins did not have cervical changes upon admission, 37% of twins were delivered within 48h. Mean for delivery weeks from admission to 36 weeks was significantly less for twin than it was for singleton gestations (32.3±1.0 vs. 35.0±0.5 weeks, respectively; Mantel-Cox X 2=41.118; p<0.001). The maternal side effects were not significantly different between the groups. No serious cardiovascular complication had been found in either group. Conclusions: Tocolysis with nifedipine is effective and safe for use in both singleton and twin gestations. Springer-Verlag, 2010 Calcium channel blocker nationallicence Nifedipine nationallicence Preterm delivery nationallicence Tocolysis nationallicence Twins nationallicence Derbent Aysel Department of Obstetrics and Gynecology, Fatih University School of Medicine, Alparslan Türkeş Street No: 57, Emek, 06510, Ankara, Turkey aut Simavli Serap Department of Obstetrics and Gynecology, Fatih University School of Medicine, Alparslan Türkeş Street No: 57, Emek, 06510, Ankara, Turkey aut Gümüş İlknur Department of Obstetrics and Gynecology, Fatih University School of Medicine, Alparslan Türkeş Street No: 57, Emek, 06510, Ankara, Turkey aut Tatli M. Department of Neonatology, Fatih University School of Medicine, Ankara, Turkey aut Turhan Nilgün Department of Obstetrics and Gynecology, Fatih University School of Medicine, Alparslan Türkeş Street No: 57, Emek, 06510, Ankara, Turkey aut Archives of Gynecology and Obstetrics Springer-Verlag 284/4(2011-10-01), 821-826 0932-0067 284:4<821 2011 284 404 https://doi.org/10.1007/s00404-010-1751-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1751-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Derbent Aysel Department of Obstetrics and Gynecology, Fatih University School of Medicine, Alparslan Türkeş Street No: 57, Emek, 06510, Ankara, Turkey aut NATIONALLICENCE 700 1- Simavli Serap Department of Obstetrics and Gynecology, Fatih University School of Medicine, Alparslan Türkeş Street No: 57, Emek, 06510, Ankara, Turkey aut NATIONALLICENCE 700 1- Gümüş İlknur Department of Obstetrics and Gynecology, Fatih University School of Medicine, Alparslan Türkeş Street No: 57, Emek, 06510, Ankara, Turkey aut NATIONALLICENCE 700 1- Tatli M. Department of Neonatology, Fatih University School of Medicine, Ankara, Turkey aut NATIONALLICENCE 700 1- Turhan Nilgün Department of Obstetrics and Gynecology, Fatih University School of Medicine, Alparslan Türkeş Street No: 57, Emek, 06510, Ankara, Turkey aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 284/4(2011-10-01), 821-826 0932-0067 284:4<821 2011 284 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer