caa a22 4500 445310693 CHVBK 20180317142628.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00404-011-1985-8 doi (NATIONALLICENCE)springer-10.1007/s00404-011-1985-8 Multiple myeloma and pregnancy: a case report and literature review [Elektronische Daten] [Daphné Borja de Mozota, Philippe Kadhel, Slimane Dermeche, Luc Multigner, Eustase Janky] Purpose: Multiple myeloma, a hematological malignancy generally affecting elderly people, was diagnosed at the beginning of the pregnancy of a 33-year-old woman. We carried out a literature review in order to evaluate the consequences of this cancer on pregnancy and of pregnancy on multiple myeloma, as to determine the specific follow-up required. Methods: A systematic search for articles of interest published between 1949 and 16 November 2010 was performed in MEDLINE, SCOPUS and EMBASE, using the words "multiple myeloma” and "pregnancy”. We identified 398 publications of potential interest, 20 of which were selected and included in the analysis. Results: The selected articles included 26 cases. No specific risk factors were identified in pregnant women. The most common presentations were bone pain and/or anemia, as in the general population. Pregnancy seemed to have no effect on multiple myeloma progression. Most pregnancies went to term, with only two medical terminations and six cesareans performed before term, due to the severity of the cancer. No effect of the cancer or its treatment by chemotherapy during pregnancy was found in the children. Conclusion: Pregnancy does not seem to be contraindicated in women with multiple myeloma. Nevertheless, the management of pregnant patients with multiple myeloma is a diagnostic, therapeutic and social challenge, requiring a multidisciplinary approach and regular follow-up. Decisions should be taken based on the severity of the disease, its prognosis and maternal choice. Springer-Verlag, 2011 Pregnancy nationallicence Multiple myeloma nationallicence Borja de Mozota Daphné Department of Obstetrics and Gynecology, Pointe-à-Pitre/Abymes University Hospital, BP 465, 97159, Pointe à Pitre Cedex, Guadeloupe, France aut Kadhel Philippe Department of Obstetrics and Gynecology, Pointe-à-Pitre/Abymes University Hospital, BP 465, 97159, Pointe à Pitre Cedex, Guadeloupe, France aut Dermeche Slimane Department of Oncology, Pointe-à-Pitre/Abymes University Hospital, Pointe à Pitre Cedex, Guadeloupe, France aut Multigner Luc Institut National de la Santé et de la Recherche Médicale (INSERM) U 625, College of Medicine, Pointe-à-Pitre, France aut Janky Eustase Department of Obstetrics and Gynecology, Pointe-à-Pitre/Abymes University Hospital, BP 465, 97159, Pointe à Pitre Cedex, Guadeloupe, France aut Archives of Gynecology and Obstetrics Springer-Verlag 284/4(2011-10-01), 945-950 0932-0067 284:4<945 2011 284 404 https://doi.org/10.1007/s00404-011-1985-8 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-011-1985-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Borja de Mozota Daphné Department of Obstetrics and Gynecology, Pointe-à-Pitre/Abymes University Hospital, BP 465, 97159, Pointe à Pitre Cedex, Guadeloupe, France aut NATIONALLICENCE 700 1- Kadhel Philippe Department of Obstetrics and Gynecology, Pointe-à-Pitre/Abymes University Hospital, BP 465, 97159, Pointe à Pitre Cedex, Guadeloupe, France aut NATIONALLICENCE 700 1- Dermeche Slimane Department of Oncology, Pointe-à-Pitre/Abymes University Hospital, Pointe à Pitre Cedex, Guadeloupe, France aut NATIONALLICENCE 700 1- Multigner Luc Institut National de la Santé et de la Recherche Médicale (INSERM) U 625, College of Medicine, Pointe-à-Pitre, France aut NATIONALLICENCE 700 1- Janky Eustase Department of Obstetrics and Gynecology, Pointe-à-Pitre/Abymes University Hospital, BP 465, 97159, Pointe à Pitre Cedex, Guadeloupe, France aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 284/4(2011-10-01), 945-950 0932-0067 284:4<945 2011 284 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer