caa a22 4500 44531074X CHVBK 20180317142628.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s00404-011-1846-5 doi (NATIONALLICENCE)springer-10.1007/s00404-011-1846-5 Small cell carcinoma of the ovary of the hypercalcaemic type: an analysis of clinical and prognostic aspects of a rare disease on the basis of cases published in the literature [Elektronische Daten] [Rebecca Estel, Andreas Hackethal, Matthias Kalder, Karsten Münstedt] Purpose: Ovarian small cell carcinoma of the hypercalcaemic type is a very rare and highly aggressive malignant disease, mainly affecting young women. Due to the rarity of this tumour entity, prospective randomised trials are unlikely to be conducted, and the only retrospective analysis based on a large case series is from 1994. Since diagnostic and treatment modalities may have changed, we initiated this analysis. Methods: The aim of our study was to review and analyse cases published since 1975 to validate former findings and to gather more information about therapy options, diagnostic and prognostic factors. A systematic literature search of the PubMed/Medline database was performed assessing all articles until September 2010. All retrieved articles were evaluated and cross-checked for references on the topic. In total, 135 cases were included, selected from 62 case reports and smaller case studies. Results: Small cell carcinoma mostly affects women with a mean age of 23.4years. They present with unspecific symptoms like abdominal pain or palpable mass, sometimes accompanied by an elevated calcium or CA-125 serum concentration. The tumour appears nearly almost unilaterally, mostly affecting the right ovary. Tumour stage is a clearly prognostic factor. Adjuvant chemotherapy consisting of etoposide, cisplatinum/carboplatinum or vinca alkaloids has shown improved survival, whereas radiotherapy has not. Conclusions: In spite of limitations this analysis provides new insights especially with respect to therapeutic aspects. This review underlines the importance of case reports in rare tumour entities in order to answer open questions. Springer-Verlag, 2011 Small cell carcinoma nationallicence Ovarian cancer nationallicence Hypercalcaemia nationallicence Systematic review nationallicence Estel Rebecca Departement of Obstetrics and Gynecology, Justus-Liebig-University of Giessen, Klinikstr. 32, 35385, Giessen, Germany aut Hackethal Andreas Departement of Obstetrics and Gynecology, Justus-Liebig-University of Giessen, Klinikstr. 32, 35385, Giessen, Germany aut Kalder Matthias Department of Gynecology and Gynecological Endocrinology and Oncology, Philipps University, Baldingerstrasse, 35043, Marburg, Germany aut Münstedt Karsten Departement of Obstetrics and Gynecology, Justus-Liebig-University of Giessen, Klinikstr. 32, 35385, Giessen, Germany aut Archives of Gynecology and Obstetrics Springer-Verlag 284/5(2011-11-01), 1277-1282 0932-0067 284:5<1277 2011 284 404 https://doi.org/10.1007/s00404-011-1846-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-011-1846-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Estel Rebecca Departement of Obstetrics and Gynecology, Justus-Liebig-University of Giessen, Klinikstr. 32, 35385, Giessen, Germany aut NATIONALLICENCE 700 1- Hackethal Andreas Departement of Obstetrics and Gynecology, Justus-Liebig-University of Giessen, Klinikstr. 32, 35385, Giessen, Germany aut NATIONALLICENCE 700 1- Kalder Matthias Department of Gynecology and Gynecological Endocrinology and Oncology, Philipps University, Baldingerstrasse, 35043, Marburg, Germany aut NATIONALLICENCE 700 1- Münstedt Karsten Departement of Obstetrics and Gynecology, Justus-Liebig-University of Giessen, Klinikstr. 32, 35385, Giessen, Germany aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 284/5(2011-11-01), 1277-1282 0932-0067 284:5<1277 2011 284 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer