caa a22 4500 445310812 CHVBK 20180317142629.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s00404-010-1766-9 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1766-9 Investigation of galectin-3 and heparanase in endometrioid and serous carcinomas of the endometrium and correlation with known predictors of survival [Elektronische Daten] [Çiğdem Ege, Metin Akbulut, Osman Zekioğlu, Necmettin Özdemir] Introduction: Inhibitors of tumor angiogenesis and metastasis are emerging as important new drug candidates for cancer therapy. Galectin-3 and heparanase have been shown to function in tumor progression and metastatic spread. Both of them exert pleiotropic effects; proliferation, cell migration, differentiation and tissue remodeling. The aim of this study was to investigate heparanase and galectin-3 expression in endometrioid and serous carcinomas of the endometrium and their relation with well-known prognostic factors, in addition to estrogen, progesterone, C-erbB-2, Ki-67 and p53. Materials and methods: Sixty-four endometrial cancers, which include 24 serous types, were obtained from previously untreated patients. Immunohistochemical analysis of 64 carcinomas, 20 endometrial hyperplasia (ten of simple hyperplasia and ten of complex atypic hyperplasia) and 20 normal endometrium (ten of proliferative and ten of secretory) was performed. Conclusion: This investigation suggests that the decreased expression of galectin-3 may be involved in the pathogenesis of endometrial carcinomas from normal endometrium to carcinoma. Also down-regulated stromal expression of galectin-3 in endometrial carcinoma may be involved in lymph node metastasis. Further studies on a larger advanced stage (FIGO stage 3-4) endometrial carcinoma group may determine the value of heparanase in the endometrial carcinoma. Springer-Verlag, 2010 Galectin-3 nationallicence Heparanase nationallicence Serous endometrial carcinoma nationallicence Endometrial hyperplasia nationallicence Ege Çiğdem Patoloji Laboratuarı, Siverek Devlet Hastanesi, 63700, Siverek/Sanliurfa, Turkey aut Akbulut Metin Pamukkale Üniversitesi Hastanesi, Morfoloji Binası, Kınıklı Kampüsü, 20070, Denizli, Turkey aut Zekioğlu Osman Patoloji Ana Bilim Dalı, Ege Üniversitesi Hastanesi, Bornova/Izmir, Turkey aut Özdemir Necmettin Patoloji Ana Bilim Dalı, Ege Üniversitesi Hastanesi, Bornova/Izmir, Turkey aut Archives of Gynecology and Obstetrics Springer-Verlag 284/5(2011-11-01), 1231-1239 0932-0067 284:5<1231 2011 284 404 https://doi.org/10.1007/s00404-010-1766-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1766-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ege Çiğdem Patoloji Laboratuarı, Siverek Devlet Hastanesi, 63700, Siverek/Sanliurfa, Turkey aut NATIONALLICENCE 700 1- Akbulut Metin Pamukkale Üniversitesi Hastanesi, Morfoloji Binası, Kınıklı Kampüsü, 20070, Denizli, Turkey aut NATIONALLICENCE 700 1- Zekioğlu Osman Patoloji Ana Bilim Dalı, Ege Üniversitesi Hastanesi, Bornova/Izmir, Turkey aut NATIONALLICENCE 700 1- Özdemir Necmettin Patoloji Ana Bilim Dalı, Ege Üniversitesi Hastanesi, Bornova/Izmir, Turkey aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 284/5(2011-11-01), 1231-1239 0932-0067 284:5<1231 2011 284 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer