caa a22 4500 445310820 CHVBK 20180317142629.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s00404-011-2008-5 doi (NATIONALLICENCE)springer-10.1007/s00404-011-2008-5 Factor V Leiden G1691A and factor II G20210A point mutations and pregnancy in North-West of Iran [Elektronische Daten] [Morteza Bagheri, Isa Rad, Fariba Nanbakhsh] Purpose: The roles of several hereditary predispositions for venous thromboembolism have been evaluated in women with habitual abortion. We studied the prevalence of FV Leiden G1691A and FII G20210A mutations in women with habitual abortion and healthy controls. Methods: 60 unrelated fertile females, as controls, and 70 unrelated women with at least three consecutive pregnancy losses entered at the present study. MAS-PCR was carried out for detection of FV Leiden G1691A and FII G20210A mutations. Results: FV Leiden G1691A mutation was not found in the studied cases and controls, that is, all of the cases and the controls had normal FV Leiden 1691GG genotype. FII 20210AA genotype was not found in any of patients or controls. 2.5% of alleles (3 out of 120 chromosomes) in controls and 15.714% of alleles (22 out of 140 chromosomes) in cases had FII 20210A mutation. The FII G20210A allele frequency was 0.157 in cases and 0.025 in controls. Regarding FII G20210A mutation, the distribution of GG, GA and AA genotypes were 48 (68.57%), 22 (31.43%) and 0 (0%) in the cases and 95 (95%), 5 (5%) and 0 (0%) in the controls, respectively. Significant differences in both FII G20210A alleles and FII G20210A genotypes frequencies were observed in the cases versus the controls. Conclusion: FII G20210A mutation is significantly associated with habitual abortion. Springer-Verlag, 2011 Factor V Leiden nationallicence Coagulation factor II nationallicence Pregnancy loss nationallicence Bagheri Morteza Genetics Department, Urmia University of Medical Sciences, Urmia, Iran aut Rad Isa Cellular and Molecular Research Center, Urmia University of Medical Sciences, Urmia, Iran aut Nanbakhsh Fariba Obstetrics and Gynecology Department, Urmia University of Medical Sciences, Urmia, Iran aut Archives of Gynecology and Obstetrics Springer-Verlag 284/5(2011-11-01), 1311-1315 0932-0067 284:5<1311 2011 284 404 https://doi.org/10.1007/s00404-011-2008-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-011-2008-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bagheri Morteza Genetics Department, Urmia University of Medical Sciences, Urmia, Iran aut NATIONALLICENCE 700 1- Rad Isa Cellular and Molecular Research Center, Urmia University of Medical Sciences, Urmia, Iran aut NATIONALLICENCE 700 1- Nanbakhsh Fariba Obstetrics and Gynecology Department, Urmia University of Medical Sciences, Urmia, Iran aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 284/5(2011-11-01), 1311-1315 0932-0067 284:5<1311 2011 284 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer