caa a22 4500 445310839 CHVBK 20180317142629.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s00404-010-1781-x doi (NATIONALLICENCE)springer-10.1007/s00404-010-1781-x Microscopic lesions of placenta and Doppler velocimetry related to fetal growth restriction [Elektronische Daten] [Natalija Vedmedovska, Dace Rezeberga, Uldis Teibe, Ivars Melderis, Gilbert Donders] Purpose: The purpose of the study was to find an association between the uterine and umbilical arteries blood flow patterns in growth-restricted (FGR) and normal fetuses and placental microscopic lesions. Methods: Fifty women with prenatally suspected and post-delivery confirmed FGR of singleton fetuses were enrolled in a case-controlled follow-up study from May 2007 to December 2008. Unselected patients with appropriately growing fetuses, matched for gestational age, served as controls. Uterine and umbilical Doppler waveforms were recorded before delivery. Results: Compared with control group with normal Doppler, FGR women with abnormal Doppler velocimetry of uterine and umbilical arteries had more intervillous thrombi (p=0.01 and p<0.0001, respectively) and villous infarctions (p=0.02 and p=0.0003, respectively). Thickening of the basal membrane and villitis was clearly linked to the FGR (p=0.006 and p=0.01). Vasculitis, on the other hand, is linked to normal growth, without affecting Doppler velocities. Conclusions: Abnormal Doppler may predict hemorrhagic and ischemic placental lesions in FGR pregnancies and may lead to future improvement of the management of current and subsequent pregnancies. Springer-Verlag, 2010 Placenta nationallicence Histological lesions nationallicence Growth restriction nationallicence Doppler nationallicence Vedmedovska Natalija Department of Obstetrics and Gynaecology, Riga Stradins University, Dzirciema Street 16, 1013, Riga, Latvia aut Rezeberga Dace Department of Obstetrics and Gynaecology, Riga Stradins University, Dzirciema Street 16, 1013, Riga, Latvia aut Teibe Uldis Department of Biostatistics, Riga Stradins University, Riga, Latvia aut Melderis Ivars University Children Hospital, Division of Pathology, Riga Stradins University, Riga, Latvia aut Donders Gilbert Department of Obstetrics and Gynaecology of the Regional Hospital Heilig Hart Tienen, University Hospital Gasthuisberg Leuven, Leuven, Belgium aut Archives of Gynecology and Obstetrics Springer-Verlag 284/5(2011-11-01), 1087-1093 0932-0067 284:5<1087 2011 284 404 https://doi.org/10.1007/s00404-010-1781-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1781-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Vedmedovska Natalija Department of Obstetrics and Gynaecology, Riga Stradins University, Dzirciema Street 16, 1013, Riga, Latvia aut NATIONALLICENCE 700 1- Rezeberga Dace Department of Obstetrics and Gynaecology, Riga Stradins University, Dzirciema Street 16, 1013, Riga, Latvia aut NATIONALLICENCE 700 1- Teibe Uldis Department of Biostatistics, Riga Stradins University, Riga, Latvia aut NATIONALLICENCE 700 1- Melderis Ivars University Children Hospital, Division of Pathology, Riga Stradins University, Riga, Latvia aut NATIONALLICENCE 700 1- Donders Gilbert Department of Obstetrics and Gynaecology of the Regional Hospital Heilig Hart Tienen, University Hospital Gasthuisberg Leuven, Leuven, Belgium aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 284/5(2011-11-01), 1087-1093 0932-0067 284:5<1087 2011 284 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer