caa a22 4500 445310847 CHVBK 20180317142629.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s00404-010-1825-2 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1825-2 Is methotrexate an acceptable treatment in the management of idiopathic granulomatous mastitis? [Elektronische Daten] [Sami Akbulut, Zulfu Arikanoglu, Ayhan Senol, Nilgun Sogutcu, Murat Basbug, Erhan Yeniaras, Yusuf Yagmur] Purpose: The treatment of choice for idiopathic granulomatous mastitis (IGM) has not yet been established. There are limited data on the use of methotrexate (MTX) in the treatment of IGM. Herein, we investigated the role of MTX in the treatment of IGM patients. Methods: We present four new cases of IGM treated with MTX and a review of the English language literature concerning the use of MTX in the treatment of IGM. Results: We prospectively investigated the clinicopathological features of four female patients (aged 28-37years) who were multiparous and had used oral contraceptives. The patients were administered 7.5-15mg MTX over 2-6months. No recurrence was detected during the follow-up period of 4-8months. In five published studies on MTX use in IGM, data were available for 12 patients aged 21-40years. In nine patients, treatment was changed to MTX because of a lack of response to steroids, recurrence or steroid-induced diabetes mellitus. Steroids were used in combination with MTX as an initial treatment choice in three patients. Satisfactory results were achieved in ten patients treated with MTX, and only two demonstrated recurrence despite the treatment and underwent mastectomy. Conclusion: MTX in the present cases of IGM was effective, prevented complications and limited corticosteroid side effects. Springer-Verlag, 2010 Methotrexate nationallicence Idiopathic granulomatous mastitis nationallicence Breast nationallicence GM : Granulomatous mastitis nationallicence IGM : Idiopathic granulomatous mastitis nationallicence DM : Diabetes mellitus nationallicence US : Ultrasonography nationallicence MG : Mammography nationallicence MRI : Magnetic resonance imaging nationallicence MTX : Methotrexate nationallicence OCs : Oral contraceptive nationallicence TB : Tuberculosis nationallicence Akbulut Sami Department of Surgery, Diyarbakir Education and Research Hospital, 21400, Diyarbakir, Turkey aut Arikanoglu Zulfu Department of Surgery, Diyarbakir Education and Research Hospital, 21400, Diyarbakir, Turkey aut Senol Ayhan Department of Radiology, Diyarbakir Education and Research Hospital, 21400, Diyarbakir, Turkey aut Sogutcu Nilgun Department of Pathology, Diyarbakir Education and Research Hospital, 21400, Diyarbakir, Turkey aut Basbug Murat Department of Surgery, Diyarbakir Education and Research Hospital, 21400, Diyarbakir, Turkey aut Yeniaras Erhan Department of Anaesthesiology, Diyarbakir Education and Research Hospital, 21400, Diyarbakir, Turkey aut Yagmur Yusuf Department of Surgery, Diyarbakir Education and Research Hospital, 21400, Diyarbakir, Turkey aut Archives of Gynecology and Obstetrics Springer-Verlag 284/5(2011-11-01), 1189-1195 0932-0067 284:5<1189 2011 284 404 https://doi.org/10.1007/s00404-010-1825-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1825-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Akbulut Sami Department of Surgery, Diyarbakir Education and Research Hospital, 21400, Diyarbakir, Turkey aut NATIONALLICENCE 700 1- Arikanoglu Zulfu Department of Surgery, Diyarbakir Education and Research Hospital, 21400, Diyarbakir, Turkey aut NATIONALLICENCE 700 1- Senol Ayhan Department of Radiology, Diyarbakir Education and Research Hospital, 21400, Diyarbakir, Turkey aut NATIONALLICENCE 700 1- Sogutcu Nilgun Department of Pathology, Diyarbakir Education and Research Hospital, 21400, Diyarbakir, Turkey aut NATIONALLICENCE 700 1- Basbug Murat Department of Surgery, Diyarbakir Education and Research Hospital, 21400, Diyarbakir, Turkey aut NATIONALLICENCE 700 1- Yeniaras Erhan Department of Anaesthesiology, Diyarbakir Education and Research Hospital, 21400, Diyarbakir, Turkey aut NATIONALLICENCE 700 1- Yagmur Yusuf Department of Surgery, Diyarbakir Education and Research Hospital, 21400, Diyarbakir, Turkey aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 284/5(2011-11-01), 1189-1195 0932-0067 284:5<1189 2011 284 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer