caa a22 4500 44531091X CHVBK 20180317142629.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s00404-011-1837-6 doi (NATIONALLICENCE)springer-10.1007/s00404-011-1837-6 Metabolic syndrome is an independent risk factor for breast cancer [Elektronische Daten] [Lakymê Porto, Karla Lora, Juliana Soares, Laura Costa] Objective: This study was aimed to assess the prevalence of metabolic syndrome in patients with breast cancer and the independent effect of metabolic syndrome on breast cancer risk. Methods: Eighty-one women aged 40-80years with breast cancer and 81 controls of similar age were screened for metabolic syndrome prevalence and breast cancer risk factors, including age at diagnosis, age at menarche, reproductive status, live births, breastfeeding, family history of breast cancer, physical activity, cigarette smoking, body mass index, and metabolic syndrome parameters. Each variable was first assessed for baseline comparisons using the univariate model, and significant variables were then added to the multivariate conditional logistic regression model. Results: Prevalence of metabolic syndrome was 59.2% in breast cancer patients, and 37% in the control group (p<0.005). A positive and independent association was observed between metabolic syndrome and breast cancer risk (odds ratio=2.49; 95% confidence interval 1.17-5.30). Conclusion: Metabolic syndrome is more prevalent in breast cancer patients and is an independent risk factor for breast cancer. Springer-Verlag, 2011 Metabolic syndrome nationallicence Breast cancer nationallicence Risk factor nationallicence Hyperinsulinemia nationallicence Insulin resistance nationallicence Porto Lakymê Division of Gynecological Endocrinology and Human Reproduction, Department of Obstetrics and Gynaecology, Medical School, University of Pernambuco, Recife, Brazil aut Lora Karla Division of Gynecological Endocrinology and Human Reproduction, Department of Obstetrics and Gynaecology, Medical School, University of Pernambuco, Recife, Brazil aut Soares Juliana Division of Gynecological Endocrinology and Human Reproduction, Department of Obstetrics and Gynaecology, Medical School, University of Pernambuco, Recife, Brazil aut Costa Laura Division of Gynecological Endocrinology and Human Reproduction, Department of Obstetrics and Gynaecology, Medical School, University of Pernambuco, Recife, Brazil aut Archives of Gynecology and Obstetrics Springer-Verlag 284/5(2011-11-01), 1271-1276 0932-0067 284:5<1271 2011 284 404 https://doi.org/10.1007/s00404-011-1837-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-011-1837-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Porto Lakymê Division of Gynecological Endocrinology and Human Reproduction, Department of Obstetrics and Gynaecology, Medical School, University of Pernambuco, Recife, Brazil aut NATIONALLICENCE 700 1- Lora Karla Division of Gynecological Endocrinology and Human Reproduction, Department of Obstetrics and Gynaecology, Medical School, University of Pernambuco, Recife, Brazil aut NATIONALLICENCE 700 1- Soares Juliana Division of Gynecological Endocrinology and Human Reproduction, Department of Obstetrics and Gynaecology, Medical School, University of Pernambuco, Recife, Brazil aut NATIONALLICENCE 700 1- Costa Laura Division of Gynecological Endocrinology and Human Reproduction, Department of Obstetrics and Gynaecology, Medical School, University of Pernambuco, Recife, Brazil aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 284/5(2011-11-01), 1271-1276 0932-0067 284:5<1271 2011 284 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer