caa a22 4500 445310936 CHVBK 20180317142629.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s00404-011-2009-4 doi (NATIONALLICENCE)springer-10.1007/s00404-011-2009-4 Recent advances in optical imaging for cervical cancer detection [Elektronische Daten] [Irene Orfanoudaki, Dimitra Kappou, Stavros Sifakis] Cervical cancer is one of the most common and lethal gynecological malignancies in both developing and developed countries, and therefore, there is a considerable interest in early diagnosis and treatment of precancerous lesions. Although the current standard care mainly based on cytology and colposcopy has reduced rates of cervical cancer morbidity and mortality, many lesions are still missed or overcalled and referred for unnecessary biopsies. Optical imaging technologies, spectroscopy approaches and high-resolution imaging methods are anticipated to improve the conventional cervical cancer screening providing in vivo diagnosis with high sensitivity and specificity. Their concept is that morphologic and biochemical properties of the cervical tissue are altered in response to its malignant transformation. In addition, contrast agents that target against specific neoplastic biomarkers can enhance the effectiveness of this new technology. Due to the unprecedented growth of these optical techniques accompanied probably by favorable cost-effectiveness, the primary detection of premalignant lesions may become more accessible in both the developing and the developed countries and can offer see-to-treat workflows and early therapeutic interventions. Springer-Verlag, 2011 Cervical cancer screening nationallicence Cervical intraepithelial lesion nationallicence Squamous intraepithelial lesion nationallicence Optical spectroscopy nationallicence Optical imaging of the uterine cervix nationallicence Orfanoudaki Irene Department of Obstetrics and Gynecology, University Hospital of Heraklion, 71201, Crete, Greece aut Kappou Dimitra Department of Obstetrics and Gynecology, University Hospital of Heraklion, 71201, Crete, Greece aut Sifakis Stavros Department of Obstetrics and Gynecology, University Hospital of Heraklion, 71201, Crete, Greece aut Archives of Gynecology and Obstetrics Springer-Verlag 284/5(2011-11-01), 1197-1208 0932-0067 284:5<1197 2011 284 404 https://doi.org/10.1007/s00404-011-2009-4 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-011-2009-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Orfanoudaki Irene Department of Obstetrics and Gynecology, University Hospital of Heraklion, 71201, Crete, Greece aut NATIONALLICENCE 700 1- Kappou Dimitra Department of Obstetrics and Gynecology, University Hospital of Heraklion, 71201, Crete, Greece aut NATIONALLICENCE 700 1- Sifakis Stavros Department of Obstetrics and Gynecology, University Hospital of Heraklion, 71201, Crete, Greece aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 284/5(2011-11-01), 1197-1208 0932-0067 284:5<1197 2011 284 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer