caa a22 4500 445310979 CHVBK 20180317142629.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s00404-010-1806-5 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1806-5 Diagnosis of endometrial nerve fibers in women with endometriosis [Elektronische Daten] [Fatemeh Aghaey Meibody, Abolfazl Mehdizadeh Kashi, Ali Zare Mirzaie, Marjan Ghajarie Bani Amam, Afsane Shariati Behbahani, Bita Zolali, Laily Najafi] Purpose: Recent studies indicated that there is a high density of small nerve fibers in the functional layer of the endometrium in women with endometriosis and that it can be used as a marker to detect endometriosis. In this study, the efficacy assessment of small nerve fibers' density as a diagnostic marker was compared in patients with and without endometriosis. Methods: In this study, women with history of pelvic pain and/or infertility who were candidates for laparoscopy or laparotomy in Rassoul hospital (2007-2009) were enrolled. Histological sections of endometrial tissue were prepared from endometrial biopsy from women with endometriosis (n=12) (1) and without endometriosis (n=15) (2). Protein gene product 9.5 and neurofilament were evaluated as marker from endometrial biopsies by immunohistochemical methods. Results: There was no statistically significant difference between two groups according to age, body mass index. Nerve fibers were detected in all endometrial biopsies from all women with endometriosis but detected only in three women without endometriosis. The mean density of nerve fibers was 2.2±4.7mm−2 in group without endometriosis and) 13.1±3.3 (in group with endometriosis (p<0.001). Women with endometriosis had significantly higher nerve fiber density in comparison with women without endometriosis. Conclusions: Our findings indicated that endometrial biopsy for detecting density of nerve fibers by usage of protein gene product 9.5, provided a reliable marker for diagnosis of endometriosis. Springer-Verlag, 2010 Endometriosis nationallicence Endometrial biopsy nationallicence Density of nerve fibers nationallicence Immunohistochemistry nationallicence Aghaey Meibody Fatemeh Minimally Invasive Surgery Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran aut Mehdizadeh Kashi Abolfazl Minimally Invasive Surgery Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran aut Zare Mirzaie Ali Minimally Invasive Surgery Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran aut Ghajarie Bani Amam Marjan Minimally Invasive Surgery Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran aut Shariati Behbahani Afsane Minimally Invasive Surgery Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran aut Zolali Bita Minimally Invasive Surgery Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran aut Najafi Laily Minimally Invasive Surgery Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran aut Archives of Gynecology and Obstetrics Springer-Verlag 284/5(2011-11-01), 1157-1162 0932-0067 284:5<1157 2011 284 404 https://doi.org/10.1007/s00404-010-1806-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1806-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Aghaey Meibody Fatemeh Minimally Invasive Surgery Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran aut NATIONALLICENCE 700 1- Mehdizadeh Kashi Abolfazl Minimally Invasive Surgery Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran aut NATIONALLICENCE 700 1- Zare Mirzaie Ali Minimally Invasive Surgery Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran aut NATIONALLICENCE 700 1- Ghajarie Bani Amam Marjan Minimally Invasive Surgery Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran aut NATIONALLICENCE 700 1- Shariati Behbahani Afsane Minimally Invasive Surgery Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran aut NATIONALLICENCE 700 1- Zolali Bita Minimally Invasive Surgery Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran aut NATIONALLICENCE 700 1- Najafi Laily Minimally Invasive Surgery Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 284/5(2011-11-01), 1157-1162 0932-0067 284:5<1157 2011 284 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer