caa a22 4500 445311010 CHVBK 20180317142629.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s00404-010-1830-5 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1830-5 Effects of elm bark extracts from Ulmus laevis on human chorion carcinoma cell lines [Elektronische Daten] [Anna-Maria Hartmann, Sibylle Abarzua, André Schlichting, Dagmar-Ulrike Richter, Peter Leinweber, Volker Briese] Purpose: The potential of substancesfrom elm bark extracts to affect cancer has been described in several studies. In this study, the anticancer effects of extracts from Ulmus laevis bark were tested in hormone-dependent gynecological tumours using human chorion carcinoma cell lines. Methods: The molecular-chemical composition of the bark extract was analysed by pyrolysis-field ionisation mass spectrometry. The influence of the extracts was determined on cell vitality and cytotoxicity in the human chorion carcinoma cell lines Jeg3 and BeWo in comparison with primary trophoblast cells. Results: The elm bark extract was mainly composed of triterpenes, phytosterols, free fatty acids and suberins with lower amounts of dilignols and lipids. The elm bark extract significantly inhibited the vitality of Jeg3 and BeWo cells but increased the vitality of primary trophoblast cells. Conclusions: Substances extracted from elm bark might have beneficial effects for the prevention of hormone-dependent tumours. Springer-Verlag, 2011 Ulmus laevis bark extract nationallicence Py-FIMS nationallicence Trophoblast cells nationallicence Human chorion carcinoma cells nationallicence Vitality nationallicence Cytotoxicity nationallicence MTT : 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide nationallicence LDH : Lactate dehydrogenase nationallicence E : 17-β-estradiol nationallicence T : Tamoxifen nationallicence Hartmann Anna-Maria Department of Obstetrics and Gynecology, Faculty of Medicine, University of Rostock, Südring 81, 18059, Rostock, Germany aut Abarzua Sibylle Department of Biochemistry, Faculty of Natural Sciences, Institute of Biological Sciences, University of Rostock, Albert-Einstein-Strasse 3, 18059, Rostock, Germany aut Schlichting André Institute for Land-Use, Faculty of Agricultural and Environmental Sciences, University of Rostock, Justus-von-Liebig-Weg 6, 18059, Rostock, Germany aut Richter Dagmar-Ulrike Department of Obstetrics and Gynecology, Faculty of Medicine, University of Rostock, Südring 81, 18059, Rostock, Germany aut Leinweber Peter Institute for Land-Use, Faculty of Agricultural and Environmental Sciences, University of Rostock, Justus-von-Liebig-Weg 6, 18059, Rostock, Germany aut Briese Volker Department of Obstetrics and Gynecology, Faculty of Medicine, University of Rostock, Südring 81, 18059, Rostock, Germany aut Archives of Gynecology and Obstetrics Springer-Verlag 284/5(2011-11-01), 1265-1269 0932-0067 284:5<1265 2011 284 404 https://doi.org/10.1007/s00404-010-1830-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1830-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hartmann Anna-Maria Department of Obstetrics and Gynecology, Faculty of Medicine, University of Rostock, Südring 81, 18059, Rostock, Germany aut NATIONALLICENCE 700 1- Abarzua Sibylle Department of Biochemistry, Faculty of Natural Sciences, Institute of Biological Sciences, University of Rostock, Albert-Einstein-Strasse 3, 18059, Rostock, Germany aut NATIONALLICENCE 700 1- Schlichting André Institute for Land-Use, Faculty of Agricultural and Environmental Sciences, University of Rostock, Justus-von-Liebig-Weg 6, 18059, Rostock, Germany aut NATIONALLICENCE 700 1- Richter Dagmar-Ulrike Department of Obstetrics and Gynecology, Faculty of Medicine, University of Rostock, Südring 81, 18059, Rostock, Germany aut NATIONALLICENCE 700 1- Leinweber Peter Institute for Land-Use, Faculty of Agricultural and Environmental Sciences, University of Rostock, Justus-von-Liebig-Weg 6, 18059, Rostock, Germany aut NATIONALLICENCE 700 1- Briese Volker Department of Obstetrics and Gynecology, Faculty of Medicine, University of Rostock, Südring 81, 18059, Rostock, Germany aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 284/5(2011-11-01), 1265-1269 0932-0067 284:5<1265 2011 284 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer