caa a22 4500 445311061 CHVBK 20180317142630.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s00404-010-1786-5 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1786-5 Pregnancy complicating systemic lupus erythematosus: a series of 86 cases [Elektronische Daten] [Qiang Wei, Yunwei Ouyang, Weiyue Zeng, Lijun Duan, Junli Ge, Hua Liao] Objective: To investigate the timing of pregnancy and pregnancy termination and its management in women with pregnancy complicating systemic lupus erythematosus (SLE). Methods: A series of 86 cases of pregnancy complicating SLE treated in our hospital from January 2005 to June 2010 were retrospectively reviewed, including 54 cases of planned pregnancy and 32 cases of unplanned pregnancy. The pregnancy courses and clinical outcomes were analyzed. Results: While 12 patients in planned pregnancy group showed active SLE during pregnancy, all 32 patients in the unplanned pregnancy group presented severe SLE complications. The incidences of pregnancy loss, preterm delivery and neonatal asphyxia in the unplanned pregnancy group were significantly higher than planned pregnancy group (P<0.05), and the infant body weight was lower in the unplanned pregnancy group (P<0.05). A total of 78 live infants were born and no mortality was reported, including 15 preterm infants and one neonatal SLE. Conclusion: Planned pregnancy during stable stage, appropriate treatment in pregnancy and close monitoring can improve the security of pregnancy complicating SLE. In situations that the drug treatment is ineffective and the mother and infant are threatened, or the fetus is mature, the pregnancy should be terminated promptly, thereby reducing the complications, and increasing the success rate of pregnancy and perinatal survival rate. Springer-Verlag, 2010 Glucocorticoids nationallicence Lupus erythematosus nationallicence Pregnancy complication nationallicence Systemic nationallicence Treatment outcomes nationallicence Wei Qiang Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, 610041, Chengdu, Sichuan, People's Republic of China aut Ouyang Yunwei Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, 610041, Chengdu, Sichuan, People's Republic of China aut Zeng Weiyue Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, 610041, Chengdu, Sichuan, People's Republic of China aut Duan Lijun Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, 610041, Chengdu, Sichuan, People's Republic of China aut Ge Junli Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, 610041, Chengdu, Sichuan, People's Republic of China aut Liao Hua Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, 610041, Chengdu, Sichuan, People's Republic of China aut Archives of Gynecology and Obstetrics Springer-Verlag 284/5(2011-11-01), 1067-1071 0932-0067 284:5<1067 2011 284 404 https://doi.org/10.1007/s00404-010-1786-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1786-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wei Qiang Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, 610041, Chengdu, Sichuan, People's Republic of China aut NATIONALLICENCE 700 1- Ouyang Yunwei Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, 610041, Chengdu, Sichuan, People's Republic of China aut NATIONALLICENCE 700 1- Zeng Weiyue Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, 610041, Chengdu, Sichuan, People's Republic of China aut NATIONALLICENCE 700 1- Duan Lijun Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, 610041, Chengdu, Sichuan, People's Republic of China aut NATIONALLICENCE 700 1- Ge Junli Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, 610041, Chengdu, Sichuan, People's Republic of China aut NATIONALLICENCE 700 1- Liao Hua Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, 610041, Chengdu, Sichuan, People's Republic of China aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 284/5(2011-11-01), 1067-1071 0932-0067 284:5<1067 2011 284 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer