caa a22 4500 44531107X CHVBK 20180317142630.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s00404-010-1834-1 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1834-1 Factor V Leiden and prothrombin G20210A in Portuguese women with recurrent miscarriage: is it worthwhile to investigate? [Elektronische Daten] [Fátima Serrano, Maria Lima, Cristina Lopes, João Almeida, Jorge Branco] Objective: To compare the prevalence of factor V Leiden (FVL) and prothrombin (PT) G20210A mutations in Portuguese women with unexplained recurrent miscarriage (RM) and a control group of parous women. Materials and methods: FVL and PT G20210A analysis were carried out in 100 women with three or more consecutive miscarriages and 100 controls with no history of pregnancy losses. Secondary analysis was made regarding gestational age at miscarriage (embryonic and fetal losses). Results: Overall, the prevalence of FVL and PT G20210A was similar in women with RM (5 and 3%) compared with controls (5 and 1%) OR 1.36 (CI 95% 0.45-4.08). In RM embryonic subgroup, PT G20210A was observed in 1.3% of women and FVL prevalence (2.6%) was inclusively lesser than that of controls. Both polymorphisms were more prevalent in women with fetal losses than in controls, although statistical significance was not reached due to the small size of the >10weeks' subgroup. Conclusion: These data indicate that neither FVL nor PT G20210A is associated with RM prior to 10weeks of gestation. Therefore, its screening is not indicated as an initial approach in Portuguese women with embryonic RM and negative personal thromboembolic history. Springer-Verlag, 2011 Factor V Leiden nationallicence Prothrombin G20210A nationallicence Recurrent miscarriage nationallicence Serrano Fátima Department of Obstetrics, Maternity Dr. Alfredo da Costa, Lisbon, Portugal aut Lima Maria Department of Social and Organizational Psychology, ISCTE-Lisbon University Institute, Lisbon, Portugal aut Lopes Cristina Department of Clinical Pathology, Central Lisbon Hospitalar Center, Lisbon, Portugal aut Almeida João Department of Clinical Pathology, Maternity Dr. Alfredo da Costa, Lisbon, Portugal aut Branco Jorge Department of Obstetrics, Maternity Dr. Alfredo da Costa, Lisbon, Portugal aut Archives of Gynecology and Obstetrics Springer-Verlag 284/5(2011-11-01), 1127-1132 0932-0067 284:5<1127 2011 284 404 https://doi.org/10.1007/s00404-010-1834-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1834-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Serrano Fátima Department of Obstetrics, Maternity Dr. Alfredo da Costa, Lisbon, Portugal aut NATIONALLICENCE 700 1- Lima Maria Department of Social and Organizational Psychology, ISCTE-Lisbon University Institute, Lisbon, Portugal aut NATIONALLICENCE 700 1- Lopes Cristina Department of Clinical Pathology, Central Lisbon Hospitalar Center, Lisbon, Portugal aut NATIONALLICENCE 700 1- Almeida João Department of Clinical Pathology, Maternity Dr. Alfredo da Costa, Lisbon, Portugal aut NATIONALLICENCE 700 1- Branco Jorge Department of Obstetrics, Maternity Dr. Alfredo da Costa, Lisbon, Portugal aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 284/5(2011-11-01), 1127-1132 0932-0067 284:5<1127 2011 284 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer