caa a22 4500 44531110X CHVBK 20180317142630.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s00404-011-1983-x doi (NATIONALLICENCE)springer-10.1007/s00404-011-1983-x Laparoscopic ovarian diathermy after clomiphene failure in polycystic ovary syndrome: is it worthwhile? A randomized controlled trial [Elektronische Daten] [Hatem Abu Hashim, Osama Foda, Essam Ghayaty, Ahmed Elawa] Purpose: Laparoscopic ovarian diathermy (LOD) represents a successful treatment option for women with clomiphene citrate (CC)-resistant polycystic ovary syndrome (PCOS). However, in case of CC failure PCOS, LOD offers several theoretical advantages. This study was conducted to compare the efficacy of LOD versus continuation of CC up to six further cycles in PCOS patients who failed to achieve pregnancy despite the previous successful CC induced ovulation. Methods: One hundred and seventy six infertile women with CC failure PCOS were selected in this randomized controlled trial. Patients (n=87) underwent LOD with 6months follow-up or received CC (n=89) up to six cycles. Outcome measures were; clinical pregnancy rate, midcycle endometrial thickness, cycle length, miscarriage and live birth rates. Results: The clinical pregnancy rate per patient and the cumulative pregnancy rate after six cycles were comparable in both groups (39 vs. 33.7% and 47 vs. 39.2%, respectively). Four twin pregnancies occurred in CC group and none in LOD group and the difference was statistically significant (p<0.05). No significant difference in midcycle endometrial thickness was observed (8.8±1.2mm vs. 7.7±1.1mm). Improvement in cycle length, miscarriage and live birth rates were comparable in both groups. No cases of ovarian hyperstimulation syndrome occurred in either group. Conclusions: LOD during the 6months follow-up period and CC for up to six further cycles are equally effective for achieving pregnancy in CC failure PCOS patients. Springer-Verlag, 2011 Polycystic ovary syndrome nationallicence Clomiphene resistance nationallicence Clomiphene failure nationallicence Laparoscopic ovarian diathermy nationallicence Abu Hashim Hatem Department of Obstetrics & Gynecology, Mansoura Faculty of Medicine, Mansoura University, Mansoura, Egypt aut Foda Osama Department of Internal Medicine, Endocrinology Unit, Mansoura Faculty of Medicine, Mansoura University, Mansoura, Egypt aut Ghayaty Essam Department of Clinical Pharmacology, Mansoura Faculty of Medicine, Mansoura University, Mansoura, Egypt aut Elawa Ahmed Department of Clinical Pathology, Mansoura Faculty of Medicine, Mansoura University, Mansoura, Egypt aut Archives of Gynecology and Obstetrics Springer-Verlag 284/5(2011-11-01), 1303-1309 0932-0067 284:5<1303 2011 284 404 https://doi.org/10.1007/s00404-011-1983-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-011-1983-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Abu Hashim Hatem Department of Obstetrics & Gynecology, Mansoura Faculty of Medicine, Mansoura University, Mansoura, Egypt aut NATIONALLICENCE 700 1- Foda Osama Department of Internal Medicine, Endocrinology Unit, Mansoura Faculty of Medicine, Mansoura University, Mansoura, Egypt aut NATIONALLICENCE 700 1- Ghayaty Essam Department of Clinical Pharmacology, Mansoura Faculty of Medicine, Mansoura University, Mansoura, Egypt aut NATIONALLICENCE 700 1- Elawa Ahmed Department of Clinical Pathology, Mansoura Faculty of Medicine, Mansoura University, Mansoura, Egypt aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 284/5(2011-11-01), 1303-1309 0932-0067 284:5<1303 2011 284 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer