caa a22 4500 445311169 CHVBK 20180317142630.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s00404-010-1667-y doi (NATIONALLICENCE)springer-10.1007/s00404-010-1667-y Influence of pregnancy and smoking on brachial artery flow-mediated dilation values and time until maximum response [Elektronische Daten] [Luis Nicolau, Wellington Martins, Francisco Gallarreta, Jailson Lima, Francisco Filho] Purpose: To evaluate the effect of pregnancy and smoking on endothelial function using brachial artery flow-mediated dilation (FMD) and to determine the time necessary until the occurrence of maximum brachial artery dilation after stimulus. Methods: This study was an observational study evaluating 133 women, who were grouped as follows: non-smoking pregnant women (N=47), smoking pregnant women (N=33), non-smoking women (N=34), and smoking pregnant women (N=19). The diameter of the brachial artery was measured at baseline and at 30, 60, 90 and 120s after stimulus. The relative change of brachial artery was determined for each of these four moments. FMD measured at 60s after stimulus was compared between the groups. Results: The maximum FMD was observed at 60s after cuff release in all groups. FMD was greater among non-smoking pregnant women compared to smoking pregnant women (11.50±5.77 vs. 8.74±4.83; p=0.03) and also between non-smoking non-pregnant women compared to smoking non-pregnant women (10.52±4.76 vs. 7.21±5.57; p=0.03). Conclusions: Maximum FMD was observed approximately 60s after stimulus in all groups regardless of smoking and pregnancy status. The smoking habit seems to lead to endothelial dysfunction both in pregnant and non-pregnant women, as demonstrated by the lower FMD in smokers. Springer-Verlag, 2010 Ultrasonography nationallicence Endothelium nationallicence Pregnancy nationallicence Smoking nationallicence Nicolau Luis Escola de Ultra-sonografia e Reciclagem Médica de Ribeirão Preto (EURP), Ribeirão Prêto, São Paulo, Brazil aut Martins Wellington Escola de Ultra-sonografia e Reciclagem Médica de Ribeirão Preto (EURP), Ribeirão Prêto, São Paulo, Brazil aut Gallarreta Francisco Escola de Ultra-sonografia e Reciclagem Médica de Ribeirão Preto (EURP), Ribeirão Prêto, São Paulo, Brazil aut Lima Jailson Escola de Ultra-sonografia e Reciclagem Médica de Ribeirão Preto (EURP), Ribeirão Prêto, São Paulo, Brazil aut Filho Francisco Escola de Ultra-sonografia e Reciclagem Médica de Ribeirão Preto (EURP), Ribeirão Prêto, São Paulo, Brazil aut Archives of Gynecology and Obstetrics Springer-Verlag 284/2(2011-08-01), 313-317 0932-0067 284:2<313 2011 284 404 https://doi.org/10.1007/s00404-010-1667-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1667-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nicolau Luis Escola de Ultra-sonografia e Reciclagem Médica de Ribeirão Preto (EURP), Ribeirão Prêto, São Paulo, Brazil aut NATIONALLICENCE 700 1- Martins Wellington Escola de Ultra-sonografia e Reciclagem Médica de Ribeirão Preto (EURP), Ribeirão Prêto, São Paulo, Brazil aut NATIONALLICENCE 700 1- Gallarreta Francisco Escola de Ultra-sonografia e Reciclagem Médica de Ribeirão Preto (EURP), Ribeirão Prêto, São Paulo, Brazil aut NATIONALLICENCE 700 1- Lima Jailson Escola de Ultra-sonografia e Reciclagem Médica de Ribeirão Preto (EURP), Ribeirão Prêto, São Paulo, Brazil aut NATIONALLICENCE 700 1- Filho Francisco Escola de Ultra-sonografia e Reciclagem Médica de Ribeirão Preto (EURP), Ribeirão Prêto, São Paulo, Brazil aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 284/2(2011-08-01), 313-317 0932-0067 284:2<313 2011 284 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer