caa a22 4500 445311258 CHVBK 20180317142630.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s00404-010-1657-0 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1657-0 E-cadherin as a prognostic marker in human serous carcinomas of the ovary: an immunohistochemical analysis [Elektronische Daten] [Darius Dian, Ansgar Brüning, Ioannis Mylonas] Introduction: Ovarian cancer is a gynecologic cancer with a high mortality rate, demonstrating the need for effective and reliable tumor markers during the staging and treatment processes. Methods: Expression of E-cadherin was immunohistochemically analyzed in 100 ovarian cancer tissue samples. Results: A significant association of E-cadherin expression with histological grading (p=0.001) and surgical stage (p=0.020) could be demonstrated. However, the staining intensity of E-cadherin was not significantly associated with progression-free, cause-specific survival or overall survival in serous ovarian carcinomas. Conclusion: The E-cadherin expression was associated with FIGO surgical staging and histological differentiation in serious ovarian carcinomas, suggesting a substantial role in the carcinogenesis of serous ovarian carcinomas. However, although patients with a strong E-cadherin staining intensity had a better prognosis, no statistical significant differences could be observed. Therefore, E-cadherin might not be a useful prognostic tumor marker in serous ovarian carcinomas. Springer-Verlag, 2010 Serous ovarian cancer nationallicence E-cadherin nationallicence Immunohistochemistry nationallicence Prognosis nationallicence Survival nationallicence Dian Darius 1st Department of Obstetrics and Gynecology, Campus Innenstadt, Ludwig-Maximilians-University Munich, Maistrasse 11, 80337, Munich, Germany aut Brüning Ansgar 1st Department of Obstetrics and Gynecology, Campus Innenstadt, Ludwig-Maximilians-University Munich, Maistrasse 11, 80337, Munich, Germany aut Mylonas Ioannis 1st Department of Obstetrics and Gynecology, Campus Innenstadt, Ludwig-Maximilians-University Munich, Maistrasse 11, 80337, Munich, Germany aut Archives of Gynecology and Obstetrics Springer-Verlag 284/2(2011-08-01), 437-443 0932-0067 284:2<437 2011 284 404 https://doi.org/10.1007/s00404-010-1657-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1657-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dian Darius 1st Department of Obstetrics and Gynecology, Campus Innenstadt, Ludwig-Maximilians-University Munich, Maistrasse 11, 80337, Munich, Germany aut NATIONALLICENCE 700 1- Brüning Ansgar 1st Department of Obstetrics and Gynecology, Campus Innenstadt, Ludwig-Maximilians-University Munich, Maistrasse 11, 80337, Munich, Germany aut NATIONALLICENCE 700 1- Mylonas Ioannis 1st Department of Obstetrics and Gynecology, Campus Innenstadt, Ludwig-Maximilians-University Munich, Maistrasse 11, 80337, Munich, Germany aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 284/2(2011-08-01), 437-443 0932-0067 284:2<437 2011 284 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer