caa a22 4500 445311290 CHVBK 20180317142630.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s00404-010-1636-5 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1636-5 Heparanase expression in term placentas of diabetic patients and healthy controls [Elektronische Daten] [Doerte Luedders, Diana Bundschuh, Amadeus Hornemann, Jana-Christin Hoerster, Philipp Boemicke, Frank Köster, Michael Bohlmann] Purpose: The prevalence of diabetic disorders in pregnancy is rising, which goes along with increased risks for maternal and foetal complications during pregnancy and delivery. The expression of the endo-β-d-glucuronidase, heparanase (HPSE), may increase under hyperglycaemic conditions, is believed to play an important role in diabetes associated morbidity outside the female reproductive tract and is expressed in the placenta throughout gestation. However, the placental expression of HPSE has not been investigated in diabetic patients. Materials and methods: Placental biopsies of 30 patients with pre-existing or gestational diabetes and 30 healthy controls were analysed by real-time PCR and immunohistochemistry with regard to the presence of HPSE at term. Results: Patients and controls were comparable with respect to foetal outcome and maternal characteristics except for maternal body mass index. We were unable to show significant differences in placental HPSE expression between diabetic patients and healthy controls. Discussion: This study suggests that HPSE expression in term placentas is not affected by maternal diabetes and thus does not contribute to pathological processes in diabetic pregnancies with deliveries at term. Springer-Verlag, 2010 Placenta nationallicence Heparanase nationallicence Expression nationallicence Diabetes nationallicence Outcome nationallicence RT-PCR nationallicence Immunohistochemistry nationallicence Luedders Doerte Department of Obstetrics and Gynecology, University Hospital of Schleswig-Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538, Lübeck, Germany aut Bundschuh Diana Department of Obstetrics and Gynecology, University Hospital of Schleswig-Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538, Lübeck, Germany aut Hornemann Amadeus Department of Obstetrics and Gynecology, University Hospital Mannheim, University of Heidelberg, 68167, Mannheim, Germany aut Hoerster Jana-Christin Department of Obstetrics and Gynecology, University Hospital of Schleswig-Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538, Lübeck, Germany aut Boemicke Philipp Department of Obstetrics and Gynecology, University Hospital of Schleswig-Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538, Lübeck, Germany aut Köster Frank Department of Obstetrics and Gynecology, University Hospital of Schleswig-Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538, Lübeck, Germany aut Bohlmann Michael Department of Obstetrics and Gynecology, University Hospital of Schleswig-Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538, Lübeck, Germany aut Archives of Gynecology and Obstetrics Springer-Verlag 284/2(2011-08-01), 287-292 0932-0067 284:2<287 2011 284 404 https://doi.org/10.1007/s00404-010-1636-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1636-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Luedders Doerte Department of Obstetrics and Gynecology, University Hospital of Schleswig-Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538, Lübeck, Germany aut NATIONALLICENCE 700 1- Bundschuh Diana Department of Obstetrics and Gynecology, University Hospital of Schleswig-Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538, Lübeck, Germany aut NATIONALLICENCE 700 1- Hornemann Amadeus Department of Obstetrics and Gynecology, University Hospital Mannheim, University of Heidelberg, 68167, Mannheim, Germany aut NATIONALLICENCE 700 1- Hoerster Jana-Christin Department of Obstetrics and Gynecology, University Hospital of Schleswig-Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538, Lübeck, Germany aut NATIONALLICENCE 700 1- Boemicke Philipp Department of Obstetrics and Gynecology, University Hospital of Schleswig-Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538, Lübeck, Germany aut NATIONALLICENCE 700 1- Köster Frank Department of Obstetrics and Gynecology, University Hospital of Schleswig-Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538, Lübeck, Germany aut NATIONALLICENCE 700 1- Bohlmann Michael Department of Obstetrics and Gynecology, University Hospital of Schleswig-Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538, Lübeck, Germany aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 284/2(2011-08-01), 287-292 0932-0067 284:2<287 2011 284 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer