caa a22 4500 44531141X CHVBK 20180317142631.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s00404-010-1685-9 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1685-9 Treatment of stage IB2, IIA bulky cervical cancer: a single-institution experience of neoadjuvant chemotherapy followed by radical hysterectomy and primary radical hysterectomy [Elektronische Daten] [Jung-Yun Lee, Yun Kim, Min-Jeong Kim, Kidong Kim, Hyun Chung, Noh-Hyun Park, Yong-Sang Song, Soon-Beom Kang] Introduction: The aim of this study was to compare the efficacy and safety of neoadjuvant chemotherapy (NAC) followed by radical hysterectomy (NAC group) with primary radical hysterectomy (RH group). Methods: We reviewed all patients with bulky stage IB-IIA cervical cancer treated at Seoul National University Hospital from January 1, 2000 to December 31, 2006. Thirty-three patients were treated with NAC prior to radical hysterectomy, and 41 patients were treated with radical hysterectomy. Results: Clinical characteristics were not significantly different between the two groups. The response rate in the NAC group was 81.8%. Operation time, estimated blood loss, and complication rate were not significantly different between the two groups. Pathologic outcomes were improved in the NAC group. Adjuvant therapy was less frequently performed in the NAC group (51.6%) than in the RH group (82.9%) (P=0.005). The 5-year progression-free survival was 90.7% in the NAC group and 81.3% in the RH group, but the difference was not statistically significant (P=0.297). Conclusion: The results of this study suggest that NAC may improve pathologic outcomes, decrease the need for adjuvant radiation therapy and have a comparable operation feasibility without affecting progression-free survival. Springer-Verlag, 2010 Cervical cancer nationallicence Neoadjuvant chemotherapy nationallicence Radical hysterectomy nationallicence Bulky tumor nationallicence Lee Jung-Yun Department of Obstetrics and Gynecology, Seoul National University College of Medicine, 28 Yongun-dong, Jongno-gu, 110-744, Seoul, Korea aut Kim Yun Department of Obstetrics and Gynecology, Seoul National University College of Medicine, 28 Yongun-dong, Jongno-gu, 110-744, Seoul, Korea aut Kim Min-Jeong Department of Obstetrics and Gynecology, Seoul National University College of Medicine, 28 Yongun-dong, Jongno-gu, 110-744, Seoul, Korea aut Kim Kidong Department of Obstetrics and Gynecology, Korea Cancer Center Hospital, Seoul, Korea aut Chung Hyun Department of Obstetrics and Gynecology, Seoul National University College of Medicine, 28 Yongun-dong, Jongno-gu, 110-744, Seoul, Korea aut Park Noh-Hyun Department of Obstetrics and Gynecology, Seoul National University College of Medicine, 28 Yongun-dong, Jongno-gu, 110-744, Seoul, Korea aut Song Yong-Sang Department of Obstetrics and Gynecology, Seoul National University College of Medicine, 28 Yongun-dong, Jongno-gu, 110-744, Seoul, Korea aut Kang Soon-Beom Department of Obstetrics and Gynecology, Seoul National University College of Medicine, 28 Yongun-dong, Jongno-gu, 110-744, Seoul, Korea aut Archives of Gynecology and Obstetrics Springer-Verlag 284/2(2011-08-01), 477-482 0932-0067 284:2<477 2011 284 404 https://doi.org/10.1007/s00404-010-1685-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1685-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lee Jung-Yun Department of Obstetrics and Gynecology, Seoul National University College of Medicine, 28 Yongun-dong, Jongno-gu, 110-744, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Yun Department of Obstetrics and Gynecology, Seoul National University College of Medicine, 28 Yongun-dong, Jongno-gu, 110-744, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Min-Jeong Department of Obstetrics and Gynecology, Seoul National University College of Medicine, 28 Yongun-dong, Jongno-gu, 110-744, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Kidong Department of Obstetrics and Gynecology, Korea Cancer Center Hospital, Seoul, Korea aut NATIONALLICENCE 700 1- Chung Hyun Department of Obstetrics and Gynecology, Seoul National University College of Medicine, 28 Yongun-dong, Jongno-gu, 110-744, Seoul, Korea aut NATIONALLICENCE 700 1- Park Noh-Hyun Department of Obstetrics and Gynecology, Seoul National University College of Medicine, 28 Yongun-dong, Jongno-gu, 110-744, Seoul, Korea aut NATIONALLICENCE 700 1- Song Yong-Sang Department of Obstetrics and Gynecology, Seoul National University College of Medicine, 28 Yongun-dong, Jongno-gu, 110-744, Seoul, Korea aut NATIONALLICENCE 700 1- Kang Soon-Beom Department of Obstetrics and Gynecology, Seoul National University College of Medicine, 28 Yongun-dong, Jongno-gu, 110-744, Seoul, Korea aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 284/2(2011-08-01), 477-482 0932-0067 284:2<477 2011 284 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer