caa a22 4500 445311487 CHVBK 20180317142631.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s00404-010-1683-y doi (NATIONALLICENCE)springer-10.1007/s00404-010-1683-y Clinicopathologic features of the nine patients with primary diffuse large B cell lymphoma of the breast [Elektronische Daten] [Mesut Seker, Ahmet Bilici, Basak Ustaalioglu, Burçak Yilmaz, Banu Ozturk, Ali Ünal, Faysal Dane, Nuriye Ozdemir, Emin Elkiran, Mehmet Kalender, Mahmut Gumus, Mustafa Benekli] Background: Non-Hodgkin lymphomas of the breast are uncommon cancers that occur as either primary extranodal diseases or secondary localizations of a systemic disease. The term "primary breast lymphoma” (PBL) is used to define malignant lymphomas primarily occurring in the breast in the absence of previously detected lymphoma localizations. In this report, we analyzed nine patients with primary diffuse large B cell lymphoma (DLBCL) of breast. Patients and methods: Patients with newly diagnosed PBLs treated between 1997 and 2009 in five institutions were retrospectively evaluated. Results: The median age of the patients with PBL was 49years (range 30-82years), and four patients had left-sided and five had right-sided disease. All of the nine patients were classified as DLBCL. Five patients with DLBCL received chemotherapy followed by involved-field or elective-field radiotherapy and four received chemotherapy alone. Complete remission (CR) following primary treatment for all patients with PBL except for two cases was obtained. In two patients, recurrence occurred. At the median follow-up of 24.2months, the 5-year OS rate was 76.2%. Univariate analysis indicated that age, ECOG PS, clinical stage, international prognostic index score, lactate dehydrogenase levels and the presence of B symptoms were not important prognostic factors in our study. Conclusions: Our series contained a small sample size, but it is interesting because it included only DLBCL cases. However, definitive conclusions about treatment and follow-up options of patients cannot be made in such a small series of patients. There are very few reports of patients with PBL treated with R-CHOP rather than CHOP alone. The followup is probably still too short and sample size very few to know how R-CHOP compares with CHOP-treated patients in other series, but this is definitely worth looking at in more detail when reasonable median follow-up has been achieved and sample size are sufficient. Springer-Verlag, 2010 Primary breast lymphoma nationallicence Diffuse large B cell lymphoma nationallicence Radiotherapy nationallicence Chemotherapy nationallicence Seker Mesut Department of Medical Oncology, Dr. Lutfi Kirdar Education and Research Hospital, Istanbul, Turkey aut Bilici Ahmet Department of Medical Oncology, Dr. Lutfi Kirdar Education and Research Hospital, Istanbul, Turkey aut Ustaalioglu Basak Department of Medical Oncology, Dr. Lutfi Kirdar Education and Research Hospital, Istanbul, Turkey aut Yilmaz Burçak Department of Medical Oncology, Dr. Lutfi Kirdar Education and Research Hospital, Istanbul, Turkey aut Ozturk Banu Department of Medical Oncology, Gazi University Medical School, Ankara, Turkey aut Ünal Ali Department of Hematology, Erciyes University Medical Faculty, Kayseri, Turkey aut Dane Faysal Department of Medical Oncology, Marmara University School Medicine, Istanbul, Turkey aut Ozdemir Nuriye Department of Medical Oncology, Ministry of Health Ankara Research and Training Hospital, Ankara, Turkey aut Elkiran Emin Department of Medical Oncology, Firat (Euphrates) University School of Medicine, Elazig, Turkey aut Kalender Mehmet Department of Medical Oncology, Gaziantep University, Gaziantep Oncology Hospital, Gaziantep, Turkey aut Gumus Mahmut Department of Medical Oncology, Dr. Lutfi Kirdar Education and Research Hospital, Istanbul, Turkey aut Benekli Mustafa Department of Medical Oncology, Gazi University Medical School, Ankara, Turkey aut Archives of Gynecology and Obstetrics Springer-Verlag 284/2(2011-08-01), 405-409 0932-0067 284:2<405 2011 284 404 https://doi.org/10.1007/s00404-010-1683-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1683-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Seker Mesut Department of Medical Oncology, Dr. Lutfi Kirdar Education and Research Hospital, Istanbul, Turkey aut NATIONALLICENCE 700 1- Bilici Ahmet Department of Medical Oncology, Dr. Lutfi Kirdar Education and Research Hospital, Istanbul, Turkey aut NATIONALLICENCE 700 1- Ustaalioglu Basak Department of Medical Oncology, Dr. Lutfi Kirdar Education and Research Hospital, Istanbul, Turkey aut NATIONALLICENCE 700 1- Yilmaz Burçak Department of Medical Oncology, Dr. Lutfi Kirdar Education and Research Hospital, Istanbul, Turkey aut NATIONALLICENCE 700 1- Ozturk Banu Department of Medical Oncology, Gazi University Medical School, Ankara, Turkey aut NATIONALLICENCE 700 1- Ünal Ali Department of Hematology, Erciyes University Medical Faculty, Kayseri, Turkey aut NATIONALLICENCE 700 1- Dane Faysal Department of Medical Oncology, Marmara University School Medicine, Istanbul, Turkey aut NATIONALLICENCE 700 1- Ozdemir Nuriye Department of Medical Oncology, Ministry of Health Ankara Research and Training Hospital, Ankara, Turkey aut NATIONALLICENCE 700 1- Elkiran Emin Department of Medical Oncology, Firat (Euphrates) University School of Medicine, Elazig, Turkey aut NATIONALLICENCE 700 1- Kalender Mehmet Department of Medical Oncology, Gaziantep University, Gaziantep Oncology Hospital, Gaziantep, Turkey aut NATIONALLICENCE 700 1- Gumus Mahmut Department of Medical Oncology, Dr. Lutfi Kirdar Education and Research Hospital, Istanbul, Turkey aut NATIONALLICENCE 700 1- Benekli Mustafa Department of Medical Oncology, Gazi University Medical School, Ankara, Turkey aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 284/2(2011-08-01), 405-409 0932-0067 284:2<405 2011 284 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer