caa a22 4500 445311509 CHVBK 20180317142631.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s00404-010-1665-0 doi (NATIONALLICENCE)springer-10.1007/s00404-010-1665-0 The impact of previous cesarean section on the success of future fetal programming pattern [Elektronische Daten] [Hamisu Salihu, Chelsea Bowen, Ronee Wilson, Phillip Marty] Purpose: The purpose of this study is to examine whether cesarean section in the first pregnancy is associated with the success or failure of programmed fetal growth phenotypes or patterns in the subsequent pregnancy. Methods: We analyzed data from a population-based retrospective cohort of singleton deliveries that occurred in the state of Missouri from 1978 to 2005 (n=1,224,133). The main outcome was neonatal mortality, which was used as an index of the success of fetal programming. Cox proportional hazard and logistic regression models were used to generate point estimates and 95% confidence intervals. Results: Mothers delivering by cesarean section in the first pregnancy were less likely to deliver subsequent appropriate-for-gestational-age (AGA) neonates (OR 0.91, 95% CI 0.89-0.92) when compared with mothers delivering vaginally. Of the 1,457 neonatal deaths in the second pregnancy, 383 early neonatal and 95 late neonatal deaths were to mothers with cesarean section deliveries in the first pregnancy. When compared with women with a previous vaginal delivery, AGA neonates of women with a primary cesarean section had 20% increased risk of both neonatal (OR 1.20, 95% CI 1.05-1.37) and early neonatal (OR 1.23, 95% CI 1.05-1.43) death. Conclusion: Our study suggests that previous cesarean section is a risk factor for neonatal mortality among AGA infants of subsequent pregnancy. Future prospective studies are needed to confirm these findings. Springer-Verlag, 2010 Cesarean section nationallicence Fetal programming nationallicence Fetal growth phenotypes nationallicence Neonatal death nationallicence Subsequent pregnancy nationallicence Salihu Hamisu Center for Research and Evaluation, Lawton and Rhea Chiles Center for Healthy Mothers and Babies, University of South Florida, 3111 E. Fletcher Avenue, 33613, Tampa, FL, USA aut Bowen Chelsea Department of Epidemiology and Biostatistics, University of South Florida, Tampa, FL, USA aut Wilson Ronee Department of Epidemiology and Biostatistics, University of South Florida, Tampa, FL, USA aut Marty Phillip Center for Research and Evaluation, Lawton and Rhea Chiles Center for Healthy Mothers and Babies, University of South Florida, 3111 E. Fletcher Avenue, 33613, Tampa, FL, USA aut Archives of Gynecology and Obstetrics Springer-Verlag 284/2(2011-08-01), 319-326 0932-0067 284:2<319 2011 284 404 https://doi.org/10.1007/s00404-010-1665-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00404-010-1665-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Salihu Hamisu Center for Research and Evaluation, Lawton and Rhea Chiles Center for Healthy Mothers and Babies, University of South Florida, 3111 E. Fletcher Avenue, 33613, Tampa, FL, USA aut NATIONALLICENCE 700 1- Bowen Chelsea Department of Epidemiology and Biostatistics, University of South Florida, Tampa, FL, USA aut NATIONALLICENCE 700 1- Wilson Ronee Department of Epidemiology and Biostatistics, University of South Florida, Tampa, FL, USA aut NATIONALLICENCE 700 1- Marty Phillip Center for Research and Evaluation, Lawton and Rhea Chiles Center for Healthy Mothers and Babies, University of South Florida, 3111 E. Fletcher Avenue, 33613, Tampa, FL, USA aut NATIONALLICENCE 773 0- Archives of Gynecology and Obstetrics Springer-Verlag 284/2(2011-08-01), 319-326 0932-0067 284:2<319 2011 284 404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer