caa a22 4500 445311584 CHVBK 20180317142632.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1007/s11095-010-0177-8 doi (NATIONALLICENCE)springer-10.1007/s11095-010-0177-8 Rapid Intradermal Delivery of Liquid Formulations Using a Hollow Microstructured Array [Elektronische Daten] [Scott Burton, Chin-Yee Ng, Ryan Simmers, Craig Moeckly, David Brandwein, Tom Gilbert, Nathan Johnson, Ken Brown, Tesha Alston, Gayatri Prochnow, Kris Siebenaler, Kris Hansen] ABSTRACT: Purpose: The purpose of this work is to demonstrate rapid intradermal delivery of up to 1.5mL of formulation using a hollow microneedle delivery device designed for self-application. Methods: 3M's hollow Microstructured Transdermal System (hMTS) was applied to domestic swine to demonstrate delivery of a variety of formulations including small molecule salts and proteins. Blood samples were collected after delivery and analyzed via HPLC or ELISA to provide a PK profile for the delivered drug. Site evaluations were conducted post delivery to determine skin tolerability. Results: Up to 1.5mL of formulation was infused into swine at a max rate of approximately 0.25mL/min. A red blotch, the size of the hMTS array, was observed immediately after patch removal, but had faded so as to be almost indistinguishable 10min post-patch removal. One-mL deliveries of commercial formulations of naloxone hydrochloride and human growth hormone and a formulation of equine anti-tetanus toxin were completed in swine. With few notable differences, the resulting PK profiles were similar to those achieved following subcutaneous injection of these formulations. Conclusions: 3M's hMTS can provide rapid, intradermal delivery of 300-1,500µL of liquid formulations of small molecules salts and proteins, compounds not typically compatible with passive transdermal delivery. The Author(s), 2010 transdermal drug delivery nationallicence microneedles nationallicence intradermal nationallicence hollow microstructures nationallicence MTS nationallicence Burton Scott 3M Drug Delivery Systems Division, Building 260-03-A-05, 55114, St. Paul, Minnesota, USA aut Ng Chin-Yee 3M Drug Delivery Systems Division, Building 260-03-A-05, 55114, St. Paul, Minnesota, USA aut Simmers Ryan 3M Drug Delivery Systems Division, Building 260-03-A-05, 55114, St. Paul, Minnesota, USA aut Moeckly Craig 3M Drug Delivery Systems Division, Building 260-03-A-05, 55114, St. Paul, Minnesota, USA aut Brandwein David 3M Drug Delivery Systems Division, Building 260-03-A-05, 55114, St. Paul, Minnesota, USA aut Gilbert Tom 3M Drug Delivery Systems Division, Building 260-03-A-05, 55114, St. Paul, Minnesota, USA aut Johnson Nathan 3M Drug Delivery Systems Division, Building 260-03-A-05, 55114, St. Paul, Minnesota, USA aut Brown Ken 3M Drug Delivery Systems Division, Building 260-03-A-05, 55114, St. Paul, Minnesota, USA aut Alston Tesha 3M Drug Delivery Systems Division, Building 260-03-A-05, 55114, St. Paul, Minnesota, USA aut Prochnow Gayatri 3M Drug Delivery Systems Division, Building 260-03-A-05, 55114, St. Paul, Minnesota, USA aut Siebenaler Kris 3M Drug Delivery Systems Division, Building 260-03-A-05, 55114, St. Paul, Minnesota, USA aut Hansen Kris 3M Drug Delivery Systems Division, Building 260-03-A-05, 55114, St. Paul, Minnesota, USA aut Pharmaceutical Research Springer US; http://www.springer-ny.com 28/1(2011-01-01), 31-40 0724-8741 28:1<31 2011 28 11095 https://doi.org/10.1007/s11095-010-0177-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11095-010-0177-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Burton Scott 3M Drug Delivery Systems Division, Building 260-03-A-05, 55114, St. Paul, Minnesota, USA aut NATIONALLICENCE 700 1- Ng Chin-Yee 3M Drug Delivery Systems Division, Building 260-03-A-05, 55114, St. Paul, Minnesota, USA aut NATIONALLICENCE 700 1- Simmers Ryan 3M Drug Delivery Systems Division, Building 260-03-A-05, 55114, St. Paul, Minnesota, USA aut NATIONALLICENCE 700 1- Moeckly Craig 3M Drug Delivery Systems Division, Building 260-03-A-05, 55114, St. Paul, Minnesota, USA aut NATIONALLICENCE 700 1- Brandwein David 3M Drug Delivery Systems Division, Building 260-03-A-05, 55114, St. Paul, Minnesota, USA aut NATIONALLICENCE 700 1- Gilbert Tom 3M Drug Delivery Systems Division, Building 260-03-A-05, 55114, St. Paul, Minnesota, USA aut NATIONALLICENCE 700 1- Johnson Nathan 3M Drug Delivery Systems Division, Building 260-03-A-05, 55114, St. Paul, Minnesota, USA aut NATIONALLICENCE 700 1- Brown Ken 3M Drug Delivery Systems Division, Building 260-03-A-05, 55114, St. Paul, Minnesota, USA aut NATIONALLICENCE 700 1- Alston Tesha 3M Drug Delivery Systems Division, Building 260-03-A-05, 55114, St. Paul, Minnesota, USA aut NATIONALLICENCE 700 1- Prochnow Gayatri 3M Drug Delivery Systems Division, Building 260-03-A-05, 55114, St. Paul, Minnesota, USA aut NATIONALLICENCE 700 1- Siebenaler Kris 3M Drug Delivery Systems Division, Building 260-03-A-05, 55114, St. Paul, Minnesota, USA aut NATIONALLICENCE 700 1- Hansen Kris 3M Drug Delivery Systems Division, Building 260-03-A-05, 55114, St. Paul, Minnesota, USA aut NATIONALLICENCE 773 0- Pharmaceutical Research Springer US; http://www.springer-ny.com 28/1(2011-01-01), 31-40 0724-8741 28:1<31 2011 28 11095 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer