caa a22 4500 445311592 CHVBK 20180317142632.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1007/s11095-010-0101-2 doi (NATIONALLICENCE)springer-10.1007/s11095-010-0101-2 Microneedles in Clinical Practice-An Exploratory Study Into the Opinions of Healthcare Professionals and the Public [Elektronische Daten] [James Birchall, Rachel Clemo, Alexander Anstey, Dai John] ABSTRACT: Purpose: Microneedles are being developed to administer vaccines and therapeutics to and through skin. To date there has been no qualitative or quantitative research into public and health professionals' views on this new delivery technique. Methods: Focus groups (n=7) comprising public and healthcare professionals were convened to capture the perceived advantages for, and concerns with, microneedles. Discussions were audio-recorded and transcribed. Transcript analysis identified themes that were explored using a questionnaire identifying consensus or otherwise. Results: Participants identified many potential benefits of the microneedle delivery system, including reduced pain, tissue damage and risk of transmitting infections compared with conventional injections, as well as potential for self-administration (subject to safeguards such as an indicator to confirm dose delivery). Delayed onset, cost, accurate and reliable dosing and the potential for misuse were raised as concerns. A range of potential clinical applications was suggested. The public (100%) and professional (74%) participants were positive overall about microneedle technology. Conclusions: This exploratory research study captured the views of the eventual end-users of microneedle technology. Microneedle researchers should now reflect on their research and development activities in the context of stakeholder engagement in order to facilitate the transfer of this new technology ‘from bench to bedside.' Springer Science+Business Media, LLC, 2010 clinical practice nationallicence healthcare professional nationallicence microneedles nationallicence perception nationallicence public nationallicence Birchall James Welsh School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, CF10 3NB, Cardiff, UK aut Clemo Rachel Welsh School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, CF10 3NB, Cardiff, UK aut Anstey Alexander Department of Dermatology, School of Medicine, Cardiff University, CF14 4XN, Cardiff, UK aut John Dai Welsh School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, CF10 3NB, Cardiff, UK aut Pharmaceutical Research Springer US; http://www.springer-ny.com 28/1(2011-01-01), 95-106 0724-8741 28:1<95 2011 28 11095 https://doi.org/10.1007/s11095-010-0101-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11095-010-0101-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Birchall James Welsh School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, CF10 3NB, Cardiff, UK aut NATIONALLICENCE 700 1- Clemo Rachel Welsh School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, CF10 3NB, Cardiff, UK aut NATIONALLICENCE 700 1- Anstey Alexander Department of Dermatology, School of Medicine, Cardiff University, CF14 4XN, Cardiff, UK aut NATIONALLICENCE 700 1- John Dai Welsh School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, CF10 3NB, Cardiff, UK aut NATIONALLICENCE 773 0- Pharmaceutical Research Springer US; http://www.springer-ny.com 28/1(2011-01-01), 95-106 0724-8741 28:1<95 2011 28 11095 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer