caa a22 4500 445311649 CHVBK 20180317142632.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1007/s11095-010-0109-7 doi (NATIONALLICENCE)springer-10.1007/s11095-010-0109-7 Enhanced Bioavailability of L-Carnitine After Painless Intradermal Delivery vs. Oral Administration in Rats [Elektronische Daten] [Suohui Zhang, Guangjiong Qin, Yan Wu, Yunhua Gao, Yuqin Qiu, Fang Li, Bai Xu] ABSTRACT: Purpose: In vitro and in vivo permeation studies were conducted to evaluate the characteristic of percutaneous administration of high hydrophilic drug L-carnitine (LC) by Functional MicroArray (FMA) painless intradermal delivery system. Methods: In vitro study was designed to assess the effects of various skins, donor concentration and hydrogels from different carbomer derivatives on the release of LC in a Franz-type diffusion cell. The LC gel patches with carbomer 980 P were prepared and successfully applied to pharmacokinetic study of SD rats with and without FMA. Intravenous injection and oral administration were performed to support pharmacokinetic calculations and comparison of bioavailability. Results: Enhanced delivery of LC using FMA was achieved in skin of different species in vitro studies. The 750mg LC gel patches were applied to rats over 6h, and approximately 27% of loaded dose was transported into rat. A 2.8-fold enhancement of absolute bioavailability for LC with FMA intradermal delivery system was observed compared with oral LC administration in vivo study. Conclusions: Both in vitro and in vivo studies demonstrated that the FMA intradermal delivery system can enhance the delivery and bioavailability of LC. Springer Science+Business Media, LLC, 2010 absolute bioavailability nationallicence functional microarray nationallicence hydrogel patch nationallicence microneedles nationallicence intradermal delivery system nationallicence L-carnitine nationallicence Zhang Suohui Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 100190, Beijing, China aut Qin Guangjiong Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 100190, Beijing, China aut Wu Yan Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 100190, Beijing, China aut Gao Yunhua Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 100190, Beijing, China aut Qiu Yuqin Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 100190, Beijing, China aut Li Fang Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 100190, Beijing, China aut Xu Bai Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 100190, Beijing, China aut Pharmaceutical Research Springer US; http://www.springer-ny.com 28/1(2011-01-01), 117-123 0724-8741 28:1<117 2011 28 11095 https://doi.org/10.1007/s11095-010-0109-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11095-010-0109-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zhang Suohui Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 100190, Beijing, China aut NATIONALLICENCE 700 1- Qin Guangjiong Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 100190, Beijing, China aut NATIONALLICENCE 700 1- Wu Yan Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 100190, Beijing, China aut NATIONALLICENCE 700 1- Gao Yunhua Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 100190, Beijing, China aut NATIONALLICENCE 700 1- Qiu Yuqin Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 100190, Beijing, China aut NATIONALLICENCE 700 1- Li Fang Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 100190, Beijing, China aut NATIONALLICENCE 700 1- Xu Bai Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 100190, Beijing, China aut NATIONALLICENCE 773 0- Pharmaceutical Research Springer US; http://www.springer-ny.com 28/1(2011-01-01), 117-123 0724-8741 28:1<117 2011 28 11095 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer