caa a22 4500 445311746 CHVBK 20180317142632.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s11095-011-0380-2 doi (NATIONALLICENCE)springer-10.1007/s11095-011-0380-2 Synthesis of Temperature-Responsive Dextran-MA/PNIPAAm Particles for Controlled Drug Delivery Using Superhydrophobic Surfaces [Elektronische Daten] [Ana Lima, Wenlong Song, Barbara Blanco-Fernandez, Carmen Alvarez-Lorenzo, João Mano] ABSTRACT: Purpose: To implement a bioinspired methodology using superhydrophobic surfaces suitable for producing smart hydrogel beads in which the bioactive substance is introduced in the particles during their formation. Methods: Several superhydrophobic surfaces, including polystyrene, aluminum and copper, were prepared. Polymeric solutions composed by photo-crosslinked dextran-methacrylated and thermal responsive poly(N-isopropylacrylamide) mixed with a protein (insulin or albumin) were dropped on the superhydrophobic surfaces, and the obtained millimetric spheres were hardened in a dry environment under UV light. Results: Spherical and non-sticky hydrogels particles were formed in few minutes on the superhydrophobic surfaces. The proteins included in the liquid formulation were homogeneously distributed in the particle network. The particles exhibited temperature-sensitive swelling, porosity and protein release rate, with the responsiveness tunable by the dextran-MA/PNIPAAm weight ratio. Conclusions: The proposed method permitted the preparation of smart hydrogel particles in one step with almost 100% encapsulation yield. The temperature-sensitive release profiles suggest that the obtained spherical-shaped biomaterials are suitable as protein carriers. These stimuli-responsive beads could have potential to be used in pharmaceutical or other biomedical applications, including tissue engineering and regenerative medicine. Springer Science+Business Media, LLC, 2011 biomimetics nationallicence delivery systems nationallicence dextran-methacrylate nationallicence encapsulation methods nationallicence inter-penetrated networks nationallicence PNIPAAm nationallicence smart systems nationallicence superhydrophobic surfaces nationallicence Lima Ana 3B's Research Group-Biomaterials Biodegradables and Biomimetics Department of Polymer Engineering, University of Minho, AvePark, Zona Industrial da Gandra S. Cláudio do Barco, 4806-909, Guimarães, Caldas das Taipas, Portugal aut Song Wenlong 3B's Research Group-Biomaterials Biodegradables and Biomimetics Department of Polymer Engineering, University of Minho, AvePark, Zona Industrial da Gandra S. Cláudio do Barco, 4806-909, Guimarães, Caldas das Taipas, Portugal aut Blanco-Fernandez Barbara Department of Farmacia y Tecnología Farmacéutica Facultad de Farmacia, Universidad de Santiago de Compostela, 15782, Santiago de Compostela, Spain aut Alvarez-Lorenzo Carmen Department of Farmacia y Tecnología Farmacéutica Facultad de Farmacia, Universidad de Santiago de Compostela, 15782, Santiago de Compostela, Spain aut Mano João 3B's Research Group-Biomaterials Biodegradables and Biomimetics Department of Polymer Engineering, University of Minho, AvePark, Zona Industrial da Gandra S. Cláudio do Barco, 4806-909, Guimarães, Caldas das Taipas, Portugal aut Pharmaceutical Research Springer US; http://www.springer-ny.com 28/6(2011-06-01), 1294-1305 0724-8741 28:6<1294 2011 28 11095 https://doi.org/10.1007/s11095-011-0380-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11095-011-0380-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lima Ana 3B's Research Group-Biomaterials Biodegradables and Biomimetics Department of Polymer Engineering, University of Minho, AvePark, Zona Industrial da Gandra S. Cláudio do Barco, 4806-909, Guimarães, Caldas das Taipas, Portugal aut NATIONALLICENCE 700 1- Song Wenlong 3B's Research Group-Biomaterials Biodegradables and Biomimetics Department of Polymer Engineering, University of Minho, AvePark, Zona Industrial da Gandra S. Cláudio do Barco, 4806-909, Guimarães, Caldas das Taipas, Portugal aut NATIONALLICENCE 700 1- Blanco-Fernandez Barbara Department of Farmacia y Tecnología Farmacéutica Facultad de Farmacia, Universidad de Santiago de Compostela, 15782, Santiago de Compostela, Spain aut NATIONALLICENCE 700 1- Alvarez-Lorenzo Carmen Department of Farmacia y Tecnología Farmacéutica Facultad de Farmacia, Universidad de Santiago de Compostela, 15782, Santiago de Compostela, Spain aut NATIONALLICENCE 700 1- Mano João 3B's Research Group-Biomaterials Biodegradables and Biomimetics Department of Polymer Engineering, University of Minho, AvePark, Zona Industrial da Gandra S. Cláudio do Barco, 4806-909, Guimarães, Caldas das Taipas, Portugal aut NATIONALLICENCE 773 0- Pharmaceutical Research Springer US; http://www.springer-ny.com 28/6(2011-06-01), 1294-1305 0724-8741 28:6<1294 2011 28 11095 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer