caa a22 4500 445311800 CHVBK 20180317142632.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s11095-011-0367-z doi (NATIONALLICENCE)springer-10.1007/s11095-011-0367-z Nano-Fibrous Tissue Engineering Scaffolds Capable of Growth Factor Delivery [Elektronische Daten] [Jiang Hu, Peter Ma] ABSTRACT: Tissue engineering aims at constructing biological substitutes to repair damaged tissues. Three-dimensional (3D) porous scaffolds are commonly utilized to define the 3D geometry of tissue engineering constructs and provide adequate pore space and surface to support cell attachment, migration, proliferation, differentiation and neo tissue genesis. Biomimetic 3D scaffolds provide synthetic microenvironments that mimic the natural regeneration microenvironments and promote tissue regeneration process. While nano-fibrous (NF) scaffolds are constructed to mimic the architecture of NF extracellular matrix, controlled-release growth factors are incorporated to modulate the regeneration process. The present article summarizes current advances in methods to fabricate NF polymer scaffolds and the technologies to incorporate controlled growth factor delivery systems into 3D scaffolds, followed by examples of accelerated regeneration when the scaffolds with growth factor releasing capacity are applied in animal models. Springer Science+Business Media, LLC, 2011 drug delivery nationallicence growth factor nationallicence nano-fibrous nationallicence polymer scaffold nationallicence tissue engineering nationallicence 3D : three-dimensional nationallicence BMP-7 : bone morphogenetic protein-7 nationallicence ECM : extra-cellular matrix nationallicence MS : microspheres nationallicence NF : nano-fibrous nationallicence NS : nanospheres nationallicence PCL : poly(ε-caprolactone) nationallicence PDGF : platelet-derived growth factor nationallicence PEO : poly(ethylene oxide) nationallicence PGA : poly(glycolic acid) nationallicence PLA : poly(lactic acid) nationallicence PLGA : poly(lactic acid-co-glycolic acid) nationallicence PLLA : poly(L-lactic acid) nationallicence SW : solid-walled nationallicence TIPS : thermally induced phase separation nationallicence Hu Jiang Department of Biologic and Materials Sciences, The University of Michigan, 1011 North University Ave., Room 2211, 48109-1078, Ann Arbor, Michigan, USA aut Ma Peter Department of Biologic and Materials Sciences, The University of Michigan, 1011 North University Ave., Room 2211, 48109-1078, Ann Arbor, Michigan, USA aut Pharmaceutical Research Springer US; http://www.springer-ny.com 28/6(2011-06-01), 1273-1281 0724-8741 28:6<1273 2011 28 11095 https://doi.org/10.1007/s11095-011-0367-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11095-011-0367-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hu Jiang Department of Biologic and Materials Sciences, The University of Michigan, 1011 North University Ave., Room 2211, 48109-1078, Ann Arbor, Michigan, USA aut NATIONALLICENCE 700 1- Ma Peter Department of Biologic and Materials Sciences, The University of Michigan, 1011 North University Ave., Room 2211, 48109-1078, Ann Arbor, Michigan, USA aut NATIONALLICENCE 773 0- Pharmaceutical Research Springer US; http://www.springer-ny.com 28/6(2011-06-01), 1273-1281 0724-8741 28:6<1273 2011 28 11095 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer