caa a22 4500 445311967 CHVBK 20180317142633.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s11095-011-0437-2 doi (NATIONALLICENCE)springer-10.1007/s11095-011-0437-2 Modelling Dermal Drug Distribution After Topical Application in Human [Elektronische Daten] [Yuri Anissimov, Michael Roberts] ABSTRACT: Purpose: To model and interpret drug distribution in the dermis and underlying tissues after topical application which is relevant to the treatment of local conditions. Methods: We created a new physiological pharmacokinetic model to describe the effect of blood flow, blood protein binding and dermal binding on the rate and depth of penetration of topical drugs into the underlying skin. We used this model to interpret literature in vivo human biopsy data on dermal drug concentration at various depths in the dermis after topical application of six substances. This interpretation was facilitated by our in vitro human dermal penetration studies in which dermal diffusion coefficient and binding were estimated. Results: The model shows that dermal diffusion alone cannot explain the in vivo data, and blood and/or lymphatic transport to deep tissues must be present for almost all of the drugs tested. Conclusion: Topical drug delivery systems for deeper tissue delivery should recognise that blood/lymphatic transport may dominate over dermal diffusion for certain compounds. Springer Science+Business Media, LLC, 2011 dermal drug distribution nationallicence modelling nationallicence percutaneous penetration nationallicence topical drug delivery nationallicence Anissimov Yuri School of Biomolecular and Physical Sciences, Griffith University, 4222, Gold Coast, Queensland, Australia aut Roberts Michael School of Medicine, University of Queensland, Princess Alexandra Hospital, 4102, Brisbane, Queensland, Australia aut Pharmaceutical Research Springer US; http://www.springer-ny.com 28/9(2011-09-01), 2119-2129 0724-8741 28:9<2119 2011 28 11095 https://doi.org/10.1007/s11095-011-0437-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11095-011-0437-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Anissimov Yuri School of Biomolecular and Physical Sciences, Griffith University, 4222, Gold Coast, Queensland, Australia aut NATIONALLICENCE 700 1- Roberts Michael School of Medicine, University of Queensland, Princess Alexandra Hospital, 4102, Brisbane, Queensland, Australia aut NATIONALLICENCE 773 0- Pharmaceutical Research Springer US; http://www.springer-ny.com 28/9(2011-09-01), 2119-2129 0724-8741 28:9<2119 2011 28 11095 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer