caa a22 4500 445311983 CHVBK 20180317142633.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s11095-011-0435-4 doi (NATIONALLICENCE)springer-10.1007/s11095-011-0435-4 Transdermal Insulin Delivery Using Microdermabrasion [Elektronische Daten] [Samantha Andrews, Jeong Lee, Seong-O Choi, Mark Prausnitz] ABSTRACT: Purpose: Transdermal insulin delivery is an attractive needle-free alternative to subcutaneous injection conventionally used to treat diabetes. However, skin's barrier properties prevent insulin permeation at useful levels. Methods: We investigated whether microdermabrasion can selectively remove skin's surface layers to increase skin permeability as a method to administer insulin to diabetic rats. We further assessed the relative roles of stratum corneum and viable epidermis as barriers to insulin delivery. Results: Pretreatment of skin with microdermabrasion to selectively remove stratum corneum did not have a significant effect on insulin delivery or reduction in blood glucose level (BGL). Removal of full epidermis by microdermabrasion significantly reduced BGL, similar to the positive control involving subcutaneous injection of 0.1U insulin. Significant pharmacokinetic differences between microdermabrasion and subcutaneous injection were faster time to peak insulin concentration after injection and larger peak insulin concentration and area-under-the-curve after microdermabrasion. Conclusions: Microdermabrasion can increase skin permeability to insulin at levels sufficient to reduce BGL. Viable epidermis is a barrier to insulin delivery such that removal of full epidermis enables significantly more insulin delivery than removal of stratum corneum alone. Springer Science+Business Media, LLC, 2011 epidermis nationallicence insulin nationallicence microdermabrasion nationallicence stratum corneum nationallicence transdermal drug delivery nationallicence Andrews Samantha Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, 30332, Atlanta, Georgia, USA aut Lee Jeong School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive, 30332-0100, Atlanta, Georgia, USA aut Choi Seong-O School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive, 30332-0100, Atlanta, Georgia, USA aut Prausnitz Mark Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, 30332, Atlanta, Georgia, USA aut Pharmaceutical Research Springer US; http://www.springer-ny.com 28/9(2011-09-01), 2110-2118 0724-8741 28:9<2110 2011 28 11095 https://doi.org/10.1007/s11095-011-0435-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11095-011-0435-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Andrews Samantha Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, 30332, Atlanta, Georgia, USA aut NATIONALLICENCE 700 1- Lee Jeong School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive, 30332-0100, Atlanta, Georgia, USA aut NATIONALLICENCE 700 1- Choi Seong-O School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive, 30332-0100, Atlanta, Georgia, USA aut NATIONALLICENCE 700 1- Prausnitz Mark Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, 30332, Atlanta, Georgia, USA aut NATIONALLICENCE 773 0- Pharmaceutical Research Springer US; http://www.springer-ny.com 28/9(2011-09-01), 2110-2118 0724-8741 28:9<2110 2011 28 11095 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer