caa a22 4500 445312106 CHVBK 20180317142633.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s11095-011-0412-y doi (NATIONALLICENCE)springer-10.1007/s11095-011-0412-y Self-Assembled and Nanostructured siRNA Delivery Systems [Elektronische Daten] [Ji Jeong, Tae Park, Sun Kim] ABSTRACT: A wide range of organic and inorganic materials have been used in the development of nano-scale self-assembling gene delivery systems to improve the therapeutic efficacy of nucleic acid drugs. Small interfering RNA (siRNA) has recently been recognized as a promising and potent nucleic acid medicine for the treatment of incurable genetic disorders including cancer; however, siRNA-based therapeutics suffer from the same delivery problems as conventional nucleic acid drugs such as plasmid DNA and antisense oligonucleotides. Many of the delivery strategies developed for nucleic acid drugs have been applied to siRNA therapeutics, but they have not produced satisfactory in vivo gene silencing efficiencies to warrant clinical trials. This review discusses recent progress in the development of self-assembled and nanostructured delivery systems for efficient siRNA-induced gene silencing and their potential application in clinical settings. Springer Science+Business Media, LLC, 2011 non-viral gene carriers nationallicence PEGylated polyplex nationallicence self-assembled nanostructures nationallicence siRNA medicines nationallicence siRNA-PEG conjugates nationallicence Jeong Ji School of Pharmacy, Sungkyunkwan University, 440-746, Suwon, South Korea aut Park Tae Department of Biological Sciences Graduate School of Nanoscience and Technology, Korea Advanced Institute of Science and Technology, 305-701, Daejeon, South Korea aut Kim Sun Severance Integrative Research Institute for Cerebral & Cardiovascular Diseases, Yonsei University Health System, 250 Seongsanno, Seodaemun-gu, 120-752, Seoul, South Korea aut Pharmaceutical Research Springer US; http://www.springer-ny.com 28/9(2011-09-01), 2072-2085 0724-8741 28:9<2072 2011 28 11095 https://doi.org/10.1007/s11095-011-0412-y text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11095-011-0412-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jeong Ji School of Pharmacy, Sungkyunkwan University, 440-746, Suwon, South Korea aut NATIONALLICENCE 700 1- Park Tae Department of Biological Sciences Graduate School of Nanoscience and Technology, Korea Advanced Institute of Science and Technology, 305-701, Daejeon, South Korea aut NATIONALLICENCE 700 1- Kim Sun Severance Integrative Research Institute for Cerebral & Cardiovascular Diseases, Yonsei University Health System, 250 Seongsanno, Seodaemun-gu, 120-752, Seoul, South Korea aut NATIONALLICENCE 773 0- Pharmaceutical Research Springer US; http://www.springer-ny.com 28/9(2011-09-01), 2072-2085 0724-8741 28:9<2072 2011 28 11095 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer