caa a22 4500 445312203 CHVBK 20180317142634.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1007/s11095-011-0401-1 doi (NATIONALLICENCE)springer-10.1007/s11095-011-0401-1 Antitumour Efficacy of Two Paclitaxel Formulations for Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in an In Vivo Rat Model [Elektronische Daten] [Wim Bouquet, Steven Deleye, Steven Staelens, Lieselotte De Smet, Nancy Van Damme, Isabelle Debergh, Wim Ceelen, Filip De Vos, Jean Paul Remon, Chris Vervaet] ABSTRACT: Purpose: To evaluate the tumour growth delay of a peritoneal carcinomatosis (PC) of colorectal origin after intraperitoneal chemotherapy with paclitaxel/randomly-methylated-β-cyclodextrin (Pac/RAME-β-CD) versus Taxol® at normo- and hyperthermic conditions in rats. Methods: Hyperthermic intraperitoneal chemotherapy (HIPEC) was performed 7days post implantation of the tumour with both formulations at a Pac concentration of 0.24mg/ml. Tumour evaluation was performed via positron emission tomography (PET) and magnetic resonance imaging (MRI) imaging, measuring tumour activity and tumour volume, respectively. Scans were taken at 2 and 7days post treatment. Results: PET and MRI data showed a significant reduction in tumour activity and tumour volume for rats treated with Pac/RAME-β-CD (at normo- and hyperthermic conditions), compared to the control group. Treatment with Taxol® did not result in a significant reduction of tumour activity and tumour volume. No significant differences between the normo- and hyperthermic conditions were observed for both formulations, indicating that hyperthermia and paclitaxel were not synergistic despite the direct cytotoxic effect of hyperthermia. Conclusion: Monitoring tumour growth via PET and MRI indicated that Pac/RAME-β-CD inclusion complexes had a significantly higher efficacy compared to Taxol® in a rat model for peritoneal carcinomatosis. Springer Science+Business Media, LLC, 2011 hyperthermic intraperitoneal chemotherapy nationallicence paclitaxel nationallicence tumour growth delay nationallicence β-cyclodextrin nationallicence Bouquet Wim Laboratory of Pharmaceutical Technology, Ghent University, Harelbekestraat 72, 9000, Ghent, Belgium aut Deleye Steven Medical Image and Signal Processing, Ghent University-IBBT, Ghent, Belgium aut Staelens Steven Medical Image and Signal Processing, Ghent University-IBBT, Ghent, Belgium aut De Smet Lieselotte Laboratory of Pharmaceutical Technology, Ghent University, Harelbekestraat 72, 9000, Ghent, Belgium aut Van Damme Nancy Department of Gastroenterology, Ghent University Hospital, Ghent, Belgium aut Debergh Isabelle Department of Gastrointestinal Surgery, Ghent University Hospital, Ghent, Belgium aut Ceelen Wim Department of Gastrointestinal Surgery, Ghent University Hospital, Ghent, Belgium aut De Vos Filip Laboratory of Radiopharmacy, Ghent University, Ghent, Belgium aut Paul Remon Jean Laboratory of Pharmaceutical Technology, Ghent University, Harelbekestraat 72, 9000, Ghent, Belgium aut Vervaet Chris Laboratory of Pharmaceutical Technology, Ghent University, Harelbekestraat 72, 9000, Ghent, Belgium aut Pharmaceutical Research Springer US; http://www.springer-ny.com 28/7(2011-07-01), 1653-1660 0724-8741 28:7<1653 2011 28 11095 https://doi.org/10.1007/s11095-011-0401-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11095-011-0401-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bouquet Wim Laboratory of Pharmaceutical Technology, Ghent University, Harelbekestraat 72, 9000, Ghent, Belgium aut NATIONALLICENCE 700 1- Deleye Steven Medical Image and Signal Processing, Ghent University-IBBT, Ghent, Belgium aut NATIONALLICENCE 700 1- Staelens Steven Medical Image and Signal Processing, Ghent University-IBBT, Ghent, Belgium aut NATIONALLICENCE 700 1- De Smet Lieselotte Laboratory of Pharmaceutical Technology, Ghent University, Harelbekestraat 72, 9000, Ghent, Belgium aut NATIONALLICENCE 700 1- Van Damme Nancy Department of Gastroenterology, Ghent University Hospital, Ghent, Belgium aut NATIONALLICENCE 700 1- Debergh Isabelle Department of Gastrointestinal Surgery, Ghent University Hospital, Ghent, Belgium aut NATIONALLICENCE 700 1- Ceelen Wim Department of Gastrointestinal Surgery, Ghent University Hospital, Ghent, Belgium aut NATIONALLICENCE 700 1- De Vos Filip Laboratory of Radiopharmacy, Ghent University, Ghent, Belgium aut NATIONALLICENCE 700 1- Paul Remon Jean Laboratory of Pharmaceutical Technology, Ghent University, Harelbekestraat 72, 9000, Ghent, Belgium aut NATIONALLICENCE 700 1- Vervaet Chris Laboratory of Pharmaceutical Technology, Ghent University, Harelbekestraat 72, 9000, Ghent, Belgium aut NATIONALLICENCE 773 0- Pharmaceutical Research Springer US; http://www.springer-ny.com 28/7(2011-07-01), 1653-1660 0724-8741 28:7<1653 2011 28 11095 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer