caa a22 4500 445312262 CHVBK 20180317142634.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1007/s11095-011-0387-8 doi (NATIONALLICENCE)springer-10.1007/s11095-011-0387-8 The Effect of Composition and Gastric Conditions on the Self-Emulsification Process of Ibuprofen-Loaded Self-Emulsifying Drug Delivery Systems: A Microscopic and Dynamic Gastric Model Study [Elektronische Daten] [Annalisa Mercuri, Antonio Passalacqua, Martin Wickham, Richard Faulks, Duncan Craig, Susan Barker] ABSTRACT: Purpose: To investigate the physical processes involved in the emulsification of self-emulsifying drug delivery systems (SEDDSs) and the use of the Dynamic Gastric Model (DGM) as a characterisation tool. Methods: SEDDSs based on soybean oil, Tween 80, Span 80 and ibuprofen were prepared and their equilibrium phase diagrams established. The emulsification behaviour in a range of media was studied using polarised light microscopy and particle sizing. The behaviour of the SEDDSs in the DGM and conventional testing equipment was assessed. Results: A range of liquid crystalline mesophases was observed, enhanced in the presence of the drug. Polarised light microscopy showed different emulsification processes in the presence and absence of the drug, which was also manifest in different droplet sizes. The droplet size distribution varied between the DGM and the USP II dissolution apparatus. Conclusions: The model SEDDS displays complex liquid crystalline behaviour which may be intimately involved in the emulsification process, which in turn may alter particle size on emulsification, although there remains a question as to the in vivo significance of this effect. Furthermore, we demonstrate that the DGM represents a very promising new method of assessing the biological fate of SEDDSs. Springer Science+Business Media, LLC, 2011 droplet size nationallicence dynamic gastric model nationallicence mechanism of self-emulsification nationallicence phase diagram nationallicence self-emulsifying systems nationallicence AGJwp : artificial gastric juice without pepsin nationallicence DGM : dynamic gastric model nationallicence HCl : hydrochloric acid nationallicence SEDDS : self-emulsifying drug delivery systems nationallicence Mercuri Annalisa School of Pharmacy, University of East Anglia, NR4 7TJ, Norwich, UK aut Passalacqua Antonio Institute of Food Research, Norwich Research Park, Colney, NR4 7UA, Norwich, UK aut Wickham Martin Institute of Food Research, Norwich Research Park, Colney, NR4 7UA, Norwich, UK aut Faulks Richard Institute of Food Research, Norwich Research Park, Colney, NR4 7UA, Norwich, UK aut Craig Duncan School of Pharmacy, University of East Anglia, NR4 7TJ, Norwich, UK aut Barker Susan School of Pharmacy, University of East Anglia, NR4 7TJ, Norwich, UK aut Pharmaceutical Research Springer US; http://www.springer-ny.com 28/7(2011-07-01), 1540-1551 0724-8741 28:7<1540 2011 28 11095 https://doi.org/10.1007/s11095-011-0387-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11095-011-0387-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mercuri Annalisa School of Pharmacy, University of East Anglia, NR4 7TJ, Norwich, UK aut NATIONALLICENCE 700 1- Passalacqua Antonio Institute of Food Research, Norwich Research Park, Colney, NR4 7UA, Norwich, UK aut NATIONALLICENCE 700 1- Wickham Martin Institute of Food Research, Norwich Research Park, Colney, NR4 7UA, Norwich, UK aut NATIONALLICENCE 700 1- Faulks Richard Institute of Food Research, Norwich Research Park, Colney, NR4 7UA, Norwich, UK aut NATIONALLICENCE 700 1- Craig Duncan School of Pharmacy, University of East Anglia, NR4 7TJ, Norwich, UK aut NATIONALLICENCE 700 1- Barker Susan School of Pharmacy, University of East Anglia, NR4 7TJ, Norwich, UK aut NATIONALLICENCE 773 0- Pharmaceutical Research Springer US; http://www.springer-ny.com 28/7(2011-07-01), 1540-1551 0724-8741 28:7<1540 2011 28 11095 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer