caa a22 4500 445312351 CHVBK 20180317142634.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1007/s11095-010-0325-1 doi (NATIONALLICENCE)springer-10.1007/s11095-010-0325-1 Protein Microarrays: Novel Developments and Applications [Elektronische Daten] [Luis Berrade, Angie Garcia, Julio Camarero] ABSTRACT: Protein microarray technology possesses some of the greatest potential for providing direct information on protein function and potential drug targets. For example, functional protein microarrays are ideal tools suited for the mapping of biological pathways. They can be used to study most major types of interactions and enzymatic activities that take place in biochemical pathways and have been used for the analysis of simultaneous multiple biomolecular interactions involving protein-protein, protein-lipid, protein-DNA and protein-small molecule interactions. Because of this unique ability to analyze many kinds of molecular interactions en masse, the requirement of very small sample amount and the potential to be miniaturized and automated, protein microarrays are extremely well suited for protein profiling, drug discovery, drug target identification and clinical prognosis and diagnosis. The aim of this review is to summarize the most recent developments in the production, applications and analysis of protein microarrays. Springer Science+Business Media, LLC, 2010 drug discovery nationallicence protein chips nationallicence protein immobilization nationallicence protein profiling nationallicence proteomics nationallicence Berrade Luis Department of Pharmacology and Pharmaceutical Sciences School of Pharmacy, University of Southern California, 1985 Zonal Avenue, PSC 616, 90033, Los Angeles, California, USA aut Garcia Angie Department of Pharmacology and Pharmaceutical Sciences School of Pharmacy, University of Southern California, 1985 Zonal Avenue, PSC 616, 90033, Los Angeles, California, USA aut Camarero Julio Department of Pharmacology and Pharmaceutical Sciences School of Pharmacy, University of Southern California, 1985 Zonal Avenue, PSC 616, 90033, Los Angeles, California, USA aut Pharmaceutical Research Springer US; http://www.springer-ny.com 28/7(2011-07-01), 1480-1499 0724-8741 28:7<1480 2011 28 11095 https://doi.org/10.1007/s11095-010-0325-1 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11095-010-0325-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Berrade Luis Department of Pharmacology and Pharmaceutical Sciences School of Pharmacy, University of Southern California, 1985 Zonal Avenue, PSC 616, 90033, Los Angeles, California, USA aut NATIONALLICENCE 700 1- Garcia Angie Department of Pharmacology and Pharmaceutical Sciences School of Pharmacy, University of Southern California, 1985 Zonal Avenue, PSC 616, 90033, Los Angeles, California, USA aut NATIONALLICENCE 700 1- Camarero Julio Department of Pharmacology and Pharmaceutical Sciences School of Pharmacy, University of Southern California, 1985 Zonal Avenue, PSC 616, 90033, Los Angeles, California, USA aut NATIONALLICENCE 773 0- Pharmaceutical Research Springer US; http://www.springer-ny.com 28/7(2011-07-01), 1480-1499 0724-8741 28:7<1480 2011 28 11095 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer