caa a22 4500 445312467 CHVBK 20180317142635.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s11095-011-0526-2 doi (NATIONALLICENCE)springer-10.1007/s11095-011-0526-2 MicroRNAs and Cancer Therapeutics [Elektronische Daten] [Man Yeung, Kuan-Teh Jeang] ABSTRACT: MicroRNAs (miRNAs) are small physiological non-coding RNAs that regulate gene expression through an RNA interference (RNAi) mechanism. The expression of miRNAs is tightly controlled both spatially and temporally. Aberrant miRNA expression has been correlated with various cancers. Recent findings suggest that some miRNAs can function as tumor suppressors or oncogenes. In model experiments, the cancer phenotype of some cells can be reverted to normal when the cells are treated with miRNA mimics or inhibitors. Here, we discuss in brief the potential utility of miRNA-based cancer therapy as well as the current limitations thwarting their useful clinical application. Springer Science + Business Media, LLC (outside the USA), 2011 HTLV-1 nationallicence leukemia nationallicence microRNA nationallicence nanoparticles nationallicence oncomiRs nationallicence CDP : cyclodextrin-containing polymer nationallicence CLL : chronic lymphocytic leukemia nationallicence CREB : cAMP response element-binding nationallicence dsRNA : double-stranded RNA nationallicence HCV : Hepatitis C virus nationallicence hTf : human transferrin nationallicence HTLV-1 : human T-cell Leukemia Virus type 1 nationallicence KSHV : Kaposi's sarcoma-associated herpesvirus nationallicence LPH : liposome-polycation-hyaluronic acid nationallicence miRNAs : microRNAs nationallicence nts : nucleotides nationallicence oncomirs : oncogenic miRNAs nationallicence PEG : polyethylene glycol nationallicence PTGS : post-transcriptional gene silencing nationallicence RISC : RNA-induced silencing complex nationallicence RNAi : RNA interference nationallicence RNAP II : RNA polymerase II nationallicence RRM2 : ribonucleotide reductase M2 nationallicence scFv : single-chain antibody fragment nationallicence TfR : targeting ligand for binding to transferrin receptors nationallicence TRBP : TAR RNA-binding protein nationallicence VEGFR-2 : vascular endothelial growth factor receptor 2 nationallicence Yeung Man State Key Laboratory of Emerging Infectious Diseases, Research Centre of Infection and Immunology, Department of Microbiology Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong, China aut Jeang Kuan-Teh Molecular Virology Section, Laboratory of Molecular Microbiology National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room 306, 9000 Rockville Pike, 20892-0460, Bethesda, Maryland, USA aut Pharmaceutical Research Springer US; http://www.springer-ny.com 28/12(2011-12-01), 3043-3049 0724-8741 28:12<3043 2011 28 11095 https://doi.org/10.1007/s11095-011-0526-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11095-011-0526-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yeung Man State Key Laboratory of Emerging Infectious Diseases, Research Centre of Infection and Immunology, Department of Microbiology Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong, China aut NATIONALLICENCE 700 1- Jeang Kuan-Teh Molecular Virology Section, Laboratory of Molecular Microbiology National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room 306, 9000 Rockville Pike, 20892-0460, Bethesda, Maryland, USA aut NATIONALLICENCE 773 0- Pharmaceutical Research Springer US; http://www.springer-ny.com 28/12(2011-12-01), 3043-3049 0724-8741 28:12<3043 2011 28 11095 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer