caa a22 4500 445312521 CHVBK 20180317142635.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s11095-011-0549-8 doi (NATIONALLICENCE)springer-10.1007/s11095-011-0549-8 Antiviral RNAi: Translating Science Towards Therapeutic Success [Elektronische Daten] [Priya Shah, David Schaffer] ABSTRACT: Viruses continuously evolve to contend with an ever-changing environment that involves transmission between hosts and sometimes species, immune responses, and in some cases therapeutic interventions. Given the high mutation rate of viruses relative to the timescales of host evolution and drug development, novel drug classes that are readily screened and translated to the clinic are needed. RNA interference (RNAi)—a natural mechanism for specific degradation of target RNAs that is conserved from plants to invertebrates and vertebrates—can potentially be harnessed to yield therapies with extensive specificity, ease of design, and broad application. In this review, we discuss basic mechanisms of action and therapeutic applications of RNAi, including design considerations and areas for future development in the field. Springer Science+Business Media, LLC, 2011 antiviral nationallicence gene therapy nationallicence RNA interference (RNAi) nationallicence viral escape nationallicence Shah Priya Department of Chemical and Biolmolecular Engineering, University of California, 94720, Berkeley, California, USA aut Schaffer David Department of Chemical and Biolmolecular Engineering, University of California, 94720, Berkeley, California, USA aut Pharmaceutical Research Springer US; http://www.springer-ny.com 28/12(2011-12-01), 2966-2982 0724-8741 28:12<2966 2011 28 11095 https://doi.org/10.1007/s11095-011-0549-8 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11095-011-0549-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Shah Priya Department of Chemical and Biolmolecular Engineering, University of California, 94720, Berkeley, California, USA aut NATIONALLICENCE 700 1- Schaffer David Department of Chemical and Biolmolecular Engineering, University of California, 94720, Berkeley, California, USA aut NATIONALLICENCE 773 0- Pharmaceutical Research Springer US; http://www.springer-ny.com 28/12(2011-12-01), 2966-2982 0724-8741 28:12<2966 2011 28 11095 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer