caa a22 4500 445312653 CHVBK 20180317142635.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s11095-011-0548-9 doi (NATIONALLICENCE)springer-10.1007/s11095-011-0548-9 microRNA Replacement Therapy for Cancer [Elektronische Daten] [Jon Henry, Ana Azevedo-Pouly, Thomas Schmittgen] ABSTRACT: microRNA are small noncoding RNAs that translationally repress their target messenger RNAs. Many microRNAs are expressed at reduced levels in tumors. microRNAs with reduced expression in cancer often regulate oncogenes, resulting in enhanced tumor growth. One therapeutic option is to restore microRNA levels in the tumor to that of the non-diseased tissue. This is possible by delivering microRNA to the tumor in the form of an oligonucleotide mimic or by expressing the microRNA in the cancer using a gene vector. This article surveys the field of oligonucleotide mimics and gene vector approaches to restore microRNA levels in tumors and reviews the literature on experimental and pre-clinical studies that have used these approaches to treat cancer. Springer Science+Business Media, LLC, 2011 microRNA mimetic nationallicence microRNA mimic nationallicence therapeutic microRNAs nationallicence cancer treatment nationallicence Henry Jon College of Pharmacy, Ohio State University, Columbus, Ohio, USA aut Azevedo-Pouly Ana College of Pharmacy, Ohio State University, Columbus, Ohio, USA aut Schmittgen Thomas College of Pharmacy, Ohio State University, Columbus, Ohio, USA aut Pharmaceutical Research Springer US; http://www.springer-ny.com 28/12(2011-12-01), 3030-3042 0724-8741 28:12<3030 2011 28 11095 https://doi.org/10.1007/s11095-011-0548-9 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11095-011-0548-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Henry Jon College of Pharmacy, Ohio State University, Columbus, Ohio, USA aut NATIONALLICENCE 700 1- Azevedo-Pouly Ana College of Pharmacy, Ohio State University, Columbus, Ohio, USA aut NATIONALLICENCE 700 1- Schmittgen Thomas College of Pharmacy, Ohio State University, Columbus, Ohio, USA aut NATIONALLICENCE 773 0- Pharmaceutical Research Springer US; http://www.springer-ny.com 28/12(2011-12-01), 3030-3042 0724-8741 28:12<3030 2011 28 11095 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer